5L50

Crystal structure of enzyme in purine metabolism

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000255	biological_process	allantoin metabolic process
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006204	biological_process	IMP catabolic process
A	0008253	molecular_function	5'-nucleotidase activity
A	0009117	biological_process	nucleotide metabolic process
A	0016740	molecular_function	transferase activity
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0046037	biological_process	GMP metabolic process
A	0046040	biological_process	IMP metabolic process
A	0046054	biological_process	dGMP metabolic process
A	0046055	biological_process	dGMP catabolic process
A	0046085	biological_process	adenosine metabolic process
A	0046872	molecular_function	metal ion binding
A	0050146	molecular_function	nucleoside phosphotransferase activity
A	0050689	biological_process	negative regulation of defense response to virus by host
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0070936	biological_process	protein K48-linked ubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL A 601

Chain	Residue
A	THR97
A	GLU374
A	GLU378
A	TYR434
A	HOH741
A	HOH812
A	HOH913

---

site_id	AC2
Number of Residues	6
Details	binding site for residue GOL A 602

Chain	Residue
A	ILE152
A	ASN154
A	HOH718
A	HOH783
A	PHE150
A	TYR151

---

site_id	AC3
Number of Residues	9
Details	binding site for residue GOL A 603

Chain	Residue
A	ASP52
A	ASP54
A	THR155
A	PHE157
A	ASP351
A	HIS352
A	HOH701
A	HOH734
A	HOH765

---

site_id	AC4
Number of Residues	8
Details	binding site for residue GOL A 604

Chain	Residue
A	ALA114
A	TYR115
A	ARG144
A	SER452
A	ARG456
A	ARG456
A	TYR457
A	HOH722

---

site_id	AC5
Number of Residues	7
Details	binding site for residue GOL A 605

Chain	Residue
A	PHE283
A	ASP284
A	LEU285
A	ILE286
A	GLY324
A	ILE325
A	HOH751

---

site_id	AC6
Number of Residues	6
Details	binding site for residue GOL A 606

Chain	Residue
A	ASP252
A	TYR253
A	VAL288
A	ASP289
A	GLY310
A	HOH704

---

site_id	AC7
Number of Residues	7
Details	binding site for residue GOL A 607

Chain	Residue
A	ASP54
A	TYR65
A	HIS209
A	LYS215
A	SER251
A	TYR255
A	HOH702

---

site_id	AC8
Number of Residues	6
Details	binding site for residue GOL A 608

Chain	Residue
A	LEU41
A	ALA42
A	LYS45
A	ARG367
A	HOH725
A	HOH744

---

site_id	AC9
Number of Residues	6
Details	binding site for residue GOL A 609

Chain	Residue
A	PHE157
A	ARG202
A	ASP206
A	HIS209
A	TYR210
A	HOH740

---

site_id	AD1
Number of Residues	7
Details	binding site for residue GOL A 610

Chain	Residue
A	THR104
A	THR147
A	GLU148
A	PHE150
A	TYR151
A	ARG195
A	GLN199

---

site_id	AD2
Number of Residues	5
Details	binding site for residue GOL A 611

Chain	Residue
A	ASP257
A	THR261
A	PRO278
A	GLN280
A	HOH761

---

site_id	AD3
Number of Residues	4
Details	binding site for residue GOL A 612

Chain	Residue
A	LEU468
A	TYR471
A	PRO472
A	PHE473

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17405878","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2J2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JCM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XCV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XCW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XJB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XJC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XCV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XCW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17405878","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2J2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JCM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17405878","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2JC9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---