Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5L4K

The human 26S proteasome lid

Functional Information from GO Data

Chain	GOid	namespace	contents
N	0000502	cellular_component	proteasome complex
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005829	cellular_component	cytosol
N	0005838	cellular_component	proteasome regulatory particle
N	0008540	cellular_component	proteasome regulatory particle, base subcomplex
N	0016020	cellular_component	membrane
N	0022624	cellular_component	proteasome accessory complex
N	0030234	molecular_function	enzyme regulator activity
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0034515	cellular_component	proteasome storage granule
N	0035578	cellular_component	azurophil granule lumen
N	0042176	biological_process	regulation of protein catabolic process
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0005198	molecular_function	structural molecule activity
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005829	cellular_component	cytosol
O	0005838	cellular_component	proteasome regulatory particle
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0007127	biological_process	meiosis I
O	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
O	0016020	cellular_component	membrane
O	0022624	cellular_component	proteasome accessory complex
O	0034774	cellular_component	secretory granule lumen
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	1904813	cellular_component	ficolin-1-rich granule lumen
P	0000502	cellular_component	proteasome complex
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005838	cellular_component	proteasome regulatory particle
P	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
P	0016020	cellular_component	membrane
P	0022624	cellular_component	proteasome accessory complex
P	0034774	cellular_component	secretory granule lumen
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0070062	cellular_component	extracellular exosome
P	1904813	cellular_component	ficolin-1-rich granule lumen
Q	0000502	cellular_component	proteasome complex
Q	0005198	molecular_function	structural molecule activity
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005838	cellular_component	proteasome regulatory particle
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
Q	0016020	cellular_component	membrane
Q	0022624	cellular_component	proteasome accessory complex
Q	0032991	cellular_component	protein-containing complex
Q	0034774	cellular_component	secretory granule lumen
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0043248	biological_process	proteasome assembly
Q	0048863	biological_process	stem cell differentiation
Q	1904813	cellular_component	ficolin-1-rich granule lumen
R	0000502	cellular_component	proteasome complex
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005654	cellular_component	nucleoplasm
R	0005829	cellular_component	cytosol
R	0005838	cellular_component	proteasome regulatory particle
R	0022624	cellular_component	proteasome accessory complex
R	0032991	cellular_component	protein-containing complex
R	0034774	cellular_component	secretory granule lumen
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	1904813	cellular_component	ficolin-1-rich granule lumen
S	0000502	cellular_component	proteasome complex
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005829	cellular_component	cytosol
S	0005838	cellular_component	proteasome regulatory particle
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
S	0016020	cellular_component	membrane
S	0022624	cellular_component	proteasome accessory complex
S	0030234	molecular_function	enzyme regulator activity
S	0034774	cellular_component	secretory granule lumen
S	0042176	biological_process	regulation of protein catabolic process
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0070062	cellular_component	extracellular exosome
S	1904813	cellular_component	ficolin-1-rich granule lumen
T	0000502	cellular_component	proteasome complex
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005829	cellular_component	cytosol
T	0005838	cellular_component	proteasome regulatory particle
T	0006508	biological_process	proteolysis
T	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
T	0022624	cellular_component	proteasome accessory complex
T	0032991	cellular_component	protein-containing complex
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0000502	cellular_component	proteasome complex
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005829	cellular_component	cytosol
U	0005838	cellular_component	proteasome regulatory particle
U	0008233	molecular_function	peptidase activity
U	0008237	molecular_function	metallopeptidase activity
U	0016020	cellular_component	membrane
U	0034774	cellular_component	secretory granule lumen
U	0042803	molecular_function	protein homodimerization activity
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0070062	cellular_component	extracellular exosome
U	0140492	molecular_function	metal-dependent deubiquitinase activity
U	1904813	cellular_component	ficolin-1-rich granule lumen
V	0000502	cellular_component	proteasome complex
V	0000724	biological_process	double-strand break repair via homologous recombination
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005829	cellular_component	cytosol
V	0006281	biological_process	DNA repair
V	0006303	biological_process	double-strand break repair via nonhomologous end joining
V	0006508	biological_process	proteolysis
V	0006511	biological_process	ubiquitin-dependent protein catabolic process
V	0006974	biological_process	DNA damage response
V	0008233	molecular_function	peptidase activity
V	0008237	molecular_function	metallopeptidase activity
V	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
V	0016579	biological_process	protein deubiquitination
V	0016787	molecular_function	hydrolase activity
V	0022624	cellular_component	proteasome accessory complex
V	0031597	cellular_component	cytosolic proteasome complex
V	0034774	cellular_component	secretory granule lumen
V	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0045471	biological_process	response to ethanol
V	0046872	molecular_function	metal ion binding
V	0061133	molecular_function	endopeptidase activator activity
V	0061136	biological_process	regulation of proteasomal protein catabolic process
V	0061578	molecular_function	K63-linked deubiquitinase activity
V	0070536	biological_process	protein K63-linked deubiquitination
V	0070628	molecular_function	proteasome binding
V	0140492	molecular_function	metal-dependent deubiquitinase activity
V	1904813	cellular_component	ficolin-1-rich granule lumen
W	0000502	cellular_component	proteasome complex
W	0003723	molecular_function	RNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005829	cellular_component	cytosol
W	0008540	cellular_component	proteasome regulatory particle, base subcomplex
W	0022624	cellular_component	proteasome accessory complex
W	0031593	molecular_function	polyubiquitin modification-dependent protein binding
W	0042802	molecular_function	identical protein binding
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0060090	molecular_function	molecular adaptor activity
Y	0000502	cellular_component	proteasome complex
Y	0000724	biological_process	double-strand break repair via homologous recombination
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005829	cellular_component	cytosol
Y	0006406	biological_process	mRNA export from nucleus
Y	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
Y	0032039	cellular_component	integrator complex
Y	0032991	cellular_component	protein-containing complex
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0043248	biological_process	proteasome assembly
Z	0000502	cellular_component	proteasome complex
Z	0005515	molecular_function	protein binding
Z	0005576	cellular_component	extracellular region
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005829	cellular_component	cytosol
Z	0005838	cellular_component	proteasome regulatory particle
Z	0008540	cellular_component	proteasome regulatory particle, base subcomplex
Z	0016020	cellular_component	membrane
Z	0022624	cellular_component	proteasome accessory complex
Z	0030234	molecular_function	enzyme regulator activity
Z	0034515	cellular_component	proteasome storage granule
Z	0034774	cellular_component	secretory granule lumen
Z	0042176	biological_process	regulation of protein catabolic process
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Z	0070062	cellular_component	extracellular exosome
Z	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. AAGFSSSGPAATSGAV

Chain	Residue	Details
T	ALA72-VAL87

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
O	LYS298
U	LYS214
V	ASP126

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P26516

Chain	Residue	Details
U	LYS316
U	LYS317

site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Chain	Residue	Details
U	LYS180

site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:25772364, ECO:0007744\|PubMed:28112733

Chain	Residue	Details
Q	LYS274
W	SER361

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:17323924, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
N	THR311

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17323924, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
N	SER315

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q3TXS7

Chain	Residue	Details
N	LYS720

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
N	THR830

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
N	SER834

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)