5L3Q
Structure of the GTPase heterodimer of human SRP54 and SRalpha
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0006614 | biological_process | SRP-dependent cotranslational protein targeting to membrane |
| A | 0008312 | molecular_function | 7S RNA binding |
| A | 0048500 | cellular_component | signal recognition particle |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005047 | molecular_function | signal recognition particle binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005785 | cellular_component | signal recognition particle receptor complex |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0006613 | biological_process | cotranslational protein targeting to membrane |
| B | 0006614 | biological_process | SRP-dependent cotranslational protein targeting to membrane |
| B | 0006617 | biological_process | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0016020 | cellular_component | membrane |
| B | 0045047 | biological_process | protein targeting to ER |
| B | 0070062 | cellular_component | extracellular exosome |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005525 | molecular_function | GTP binding |
| C | 0006614 | biological_process | SRP-dependent cotranslational protein targeting to membrane |
| C | 0008312 | molecular_function | 7S RNA binding |
| C | 0048500 | cellular_component | signal recognition particle |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003723 | molecular_function | RNA binding |
| D | 0003924 | molecular_function | GTPase activity |
| D | 0005047 | molecular_function | signal recognition particle binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005525 | molecular_function | GTP binding |
| D | 0005785 | cellular_component | signal recognition particle receptor complex |
| D | 0005789 | cellular_component | endoplasmic reticulum membrane |
| D | 0006613 | biological_process | cotranslational protein targeting to membrane |
| D | 0006614 | biological_process | SRP-dependent cotranslational protein targeting to membrane |
| D | 0006617 | biological_process | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition |
| D | 0006886 | biological_process | intracellular protein transport |
| D | 0016020 | cellular_component | membrane |
| D | 0045047 | biological_process | protein targeting to ER |
| D | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 501 |
| Chain | Residue |
| A | LYS154 |
| A | HIS278 |
| A | ILE279 |
| A | AMP505 |
| B | GOL707 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | binding site for residue GNP A 502 |
| Chain | Residue |
| A | LYS114 |
| A | THR115 |
| A | THR116 |
| A | LYS120 |
| A | ASP138 |
| A | ARG141 |
| A | GLN147 |
| A | GLY193 |
| A | LYS249 |
| A | ASP251 |
| A | GLY274 |
| A | THR275 |
| A | GLY276 |
| A | GLU277 |
| A | MG503 |
| A | HOH603 |
| A | HOH609 |
| B | ASN427 |
| B | ARG458 |
| B | GNP705 |
| A | GLN110 |
| A | GLY111 |
| A | SER112 |
| A | GLY113 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 503 |
| Chain | Residue |
| A | THR115 |
| A | GNP502 |
| A | HOH601 |
| A | HOH609 |
| A | HOH610 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | LYS286 |
| A | THR287 |
| A | GLN288 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue AMP A 505 |
| Chain | Residue |
| A | GLU277 |
| A | HIS278 |
| A | SO4501 |
| A | HOH607 |
| A | HOH618 |
| A | HOH619 |
| B | PHE457 |
| B | GLY523 |
| B | LEU531 |
| B | GOL707 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 701 |
| Chain | Residue |
| B | ARG466 |
| B | ARG470 |
| B | HOH803 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 702 |
| Chain | Residue |
| B | LYS496 |
| B | ASP497 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 703 |
| Chain | Residue |
| B | THR467 |
| B | ARG470 |
| B | HOH827 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 704 |
| Chain | Residue |
| B | ASP497 |
| B | MET503 |
| B | LYS537 |
| B | VAL541 |
| site_id | AD1 |
| Number of Residues | 26 |
| Details | binding site for residue GNP B 705 |
| Chain | Residue |
| A | GLN110 |
| A | ARG141 |
| A | GNP502 |
| B | ASN427 |
| B | GLY428 |
| B | VAL429 |
| B | GLY430 |
| B | LYS431 |
| B | SER432 |
| B | THR433 |
| B | ASN434 |
| B | LYS437 |
| B | ARG458 |
| B | GLN464 |
| B | LYS589 |
| B | ASP591 |
| B | GLY615 |
| B | THR616 |
| B | GLY617 |
| B | GLN618 |
| B | MG706 |
| B | HOH804 |
| B | HOH805 |
| B | HOH809 |
| B | HOH816 |
| B | HOH819 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 706 |
| Chain | Residue |
| B | SER432 |
| B | ASP520 |
| B | GNP705 |
| B | HOH804 |
| B | HOH805 |
| B | HOH819 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 707 |
| Chain | Residue |
| A | LYS154 |
| A | SO4501 |
| A | AMP505 |
| B | PHE457 |
| B | ALA459 |
| B | HOH822 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 501 |
| Chain | Residue |
| C | LYS47 |
| D | LYS596 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 C 502 |
| Chain | Residue |
| C | LYS154 |
| C | HIS278 |
| C | ILE279 |
| D | GOL705 |
| site_id | AD6 |
| Number of Residues | 29 |
| Details | binding site for residue GNP C 503 |
| Chain | Residue |
| C | GLN110 |
| C | GLY111 |
| C | SER112 |
| C | GLY113 |
| C | LYS114 |
| C | THR115 |
| C | THR116 |
| C | LYS120 |
| C | ASP138 |
| C | ARG141 |
| C | GLN147 |
| C | GLY193 |
| C | LYS249 |
| C | ASP251 |
| C | GLY274 |
| C | THR275 |
| C | GLY276 |
| C | GLU277 |
| C | MG504 |
| C | HOH601 |
| C | HOH602 |
| C | HOH603 |
| C | HOH606 |
| C | HOH607 |
| C | HOH611 |
| D | ASN427 |
| D | ARG458 |
| D | GNP703 |
| D | HOH819 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 504 |
| Chain | Residue |
| C | THR115 |
| C | GNP503 |
| C | HOH601 |
| C | HOH602 |
| C | HOH603 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue GOL C 505 |
| Chain | Residue |
| C | HIS253 |
| D | LYS565 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue AMP C 506 |
| Chain | Residue |
| C | GLU277 |
| C | HIS278 |
| C | HOH605 |
| C | HOH609 |
| D | PHE457 |
| D | GLY523 |
| D | LEU531 |
| D | GOL705 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 D 701 |
| Chain | Residue |
| D | ARG470 |
| D | ARG471 |
| site_id | AE2 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 D 702 |
| Chain | Residue |
| D | ASP497 |
| site_id | AE3 |
| Number of Residues | 26 |
| Details | binding site for residue GNP D 703 |
| Chain | Residue |
| C | GLN110 |
| C | ARG141 |
| C | GNP503 |
| D | ASN427 |
| D | GLY428 |
| D | VAL429 |
| D | GLY430 |
| D | LYS431 |
| D | SER432 |
| D | THR433 |
| D | ASN434 |
| D | LYS437 |
| D | ARG458 |
| D | GLN464 |
| D | GLY523 |
| D | LYS589 |
| D | ASP591 |
| D | GLY615 |
| D | THR616 |
| D | GLY617 |
| D | GLN618 |
| D | MG704 |
| D | HOH802 |
| D | HOH803 |
| D | HOH804 |
| D | HOH812 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 704 |
| Chain | Residue |
| D | SER432 |
| D | ARG458 |
| D | GNP703 |
| D | HOH804 |
| D | HOH808 |
| D | HOH812 |
| site_id | AE5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 705 |
| Chain | Residue |
| C | ASN151 |
| C | LYS154 |
| C | SO4502 |
| C | AMP506 |
| C | HOH606 |
| D | PHE457 |
| D | ARG458 |
| D | ALA459 |
| D | HOH825 |
Functional Information from PROSITE/UniProt
| site_id | PS00300 |
| Number of Residues | 14 |
| Details | SRP54 SRP54-type proteins GTP-binding domain signature. PIiFIGTGEhIddF |
| Chain | Residue | Details |
| A | PRO269-PHE282 | |
| B | PRO610-LEU623 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 56 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 434 |
| Details | Region: {"description":"NG domain","evidences":[{"source":"PubMed","id":"34020957","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
