5L3F

LSD1-CoREST1 in complex with polymyxin B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0016491	molecular_function	oxidoreductase activity
A	0050660	molecular_function	flavin adenine dinucleotide binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	34
Details	binding site for residue FAD A 901

Chain	Residue
A	GLY285
A	GLY315
A	ARG316
A	VAL317
A	LEU329
A	GLY330
A	ALA331
A	MET332
A	VAL333
A	THR588
A	VAL590
A	GLY287
A	THR624
A	LEU625
A	PRO626
A	VAL637
A	LEU659
A	TRP751
A	TRP756
A	SER760
A	TYR761
A	GLY800
A	VAL288
A	GLU801
A	ALA809
A	THR810
A	VAL811
A	ALA814
A	SER289
A	LEU307
A	GLU308
A	ALA309
A	ARG310
A	GLY314

---

site_id	AC2
Number of Residues	2
Details	binding site for residues 6FH C 1 and 4FO C 2

Chain	Residue
C	DTH3
C	4FO4

---

site_id	AC3
Number of Residues	8
Details	binding site for residues 4FO C 4 and 4FO C 5

Chain	Residue
A	ASP553
A	ASP556
A	GLU559
C	4FO2
C	DTH3
C	DAB6
C	PHE7
C	DTH11

---

site_id	AC4
Number of Residues	6
Details	binding site for residues 4FO C 5 and DAB C 6

Chain	Residue
A	ASP556
A	GLU559
C	DTH3
C	4FO4
C	PHE7
C	DTH11

---

site_id	AC5
Number of Residues	8
Details	binding site for residues DAB C 9 and DAB C 10

Chain	Residue
A	THR335
A	ASN540
A	ASP555
A	GLU559
A	HIS564
C	PHE7
C	LEU8
C	DTH11

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	ASN460
A	GLU308
A	ARG310
A	ARG316
A	MET332
A	GLU801
A	THR810

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
B	GLU466

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER131

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	TYR135

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER137

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER166

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:27292636

Chain	Residue	Details
A	LYS432
A	LYS433
A	LYS436

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER611

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	SER849

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS442
A	LYS469

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:25018020

Chain	Residue	Details
A	LYS503

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