5L1T
X-ray Structure of M77S mutant of Cytochrome P450 PntM with pentalenolactone F
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0006707 | biological_process | cholesterol catabolic process |
| A | 0008395 | molecular_function | steroid hydroxylase activity |
| A | 0016636 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0017000 | biological_process | antibiotic biosynthetic process |
| A | 0020037 | molecular_function | heme binding |
| A | 0036199 | molecular_function | cholest-4-en-3-one 26-monooxygenase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055114 | biological_process | obsolete oxidation-reduction process |
| A | 1901780 | biological_process | pentalenolactone biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue 7PF A 401 |
| Chain | Residue |
| A | ARG74 |
| A | HOH629 |
| A | HOH678 |
| A | HOH688 |
| A | THR236 |
| A | ARG240 |
| A | ASN283 |
| A | LEU285 |
| A | PRO287 |
| A | ILE387 |
| A | THR388 |
| A | HEM402 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue HEM A 402 |
| Chain | Residue |
| A | MET81 |
| A | HIS93 |
| A | ARG97 |
| A | PHE232 |
| A | GLY233 |
| A | THR236 |
| A | THR237 |
| A | ARG240 |
| A | ILE286 |
| A | ARG288 |
| A | ALA339 |
| A | PHE340 |
| A | ARG345 |
| A | CYS347 |
| A | GLY349 |
| A | 7PF401 |
| A | HOH576 |
| A | HOH629 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGhGARHCIG |
| Chain | Residue | Details |
| A | PHE340-GLY349 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: axial binding residue => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS347 |
