5L13
Structure of ALDH2 in complex with 2P3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| A | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006066 | biological_process | alcohol metabolic process |
| A | 0006068 | biological_process | ethanol catabolic process |
| A | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase activity |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0018547 | molecular_function | nitroglycerin reductase activity |
| A | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| A | 0046185 | biological_process | aldehyde catabolic process |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0106435 | molecular_function | carboxylesterase activity |
| A | 1903179 | biological_process | regulation of dopamine biosynthetic process |
| A | 1905627 | biological_process | regulation of serotonin biosynthetic process |
| B | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| B | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006066 | biological_process | alcohol metabolic process |
| B | 0006068 | biological_process | ethanol catabolic process |
| B | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase activity |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0018547 | molecular_function | nitroglycerin reductase activity |
| B | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| B | 0046185 | biological_process | aldehyde catabolic process |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0106435 | molecular_function | carboxylesterase activity |
| B | 1903179 | biological_process | regulation of dopamine biosynthetic process |
| B | 1905627 | biological_process | regulation of serotonin biosynthetic process |
| C | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| C | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006066 | biological_process | alcohol metabolic process |
| C | 0006068 | biological_process | ethanol catabolic process |
| C | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase activity |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0018547 | molecular_function | nitroglycerin reductase activity |
| C | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| C | 0046185 | biological_process | aldehyde catabolic process |
| C | 0051287 | molecular_function | NAD binding |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0106435 | molecular_function | carboxylesterase activity |
| C | 1903179 | biological_process | regulation of dopamine biosynthetic process |
| C | 1905627 | biological_process | regulation of serotonin biosynthetic process |
| D | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| D | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005759 | cellular_component | mitochondrial matrix |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006066 | biological_process | alcohol metabolic process |
| D | 0006068 | biological_process | ethanol catabolic process |
| D | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase activity |
| D | 0009055 | molecular_function | electron transfer activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0018547 | molecular_function | nitroglycerin reductase activity |
| D | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| D | 0046185 | biological_process | aldehyde catabolic process |
| D | 0051287 | molecular_function | NAD binding |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0106435 | molecular_function | carboxylesterase activity |
| D | 1903179 | biological_process | regulation of dopamine biosynthetic process |
| D | 1905627 | biological_process | regulation of serotonin biosynthetic process |
| E | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| E | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0005759 | cellular_component | mitochondrial matrix |
| E | 0005975 | biological_process | carbohydrate metabolic process |
| E | 0006066 | biological_process | alcohol metabolic process |
| E | 0006068 | biological_process | ethanol catabolic process |
| E | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase activity |
| E | 0009055 | molecular_function | electron transfer activity |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| E | 0018547 | molecular_function | nitroglycerin reductase activity |
| E | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| E | 0046185 | biological_process | aldehyde catabolic process |
| E | 0051287 | molecular_function | NAD binding |
| E | 0070062 | cellular_component | extracellular exosome |
| E | 0106435 | molecular_function | carboxylesterase activity |
| E | 1903179 | biological_process | regulation of dopamine biosynthetic process |
| E | 1905627 | biological_process | regulation of serotonin biosynthetic process |
| F | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| F | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005759 | cellular_component | mitochondrial matrix |
| F | 0005975 | biological_process | carbohydrate metabolic process |
| F | 0006066 | biological_process | alcohol metabolic process |
| F | 0006068 | biological_process | ethanol catabolic process |
| F | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase activity |
| F | 0009055 | molecular_function | electron transfer activity |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| F | 0018547 | molecular_function | nitroglycerin reductase activity |
| F | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| F | 0046185 | biological_process | aldehyde catabolic process |
| F | 0051287 | molecular_function | NAD binding |
| F | 0070062 | cellular_component | extracellular exosome |
| F | 0106435 | molecular_function | carboxylesterase activity |
| F | 1903179 | biological_process | regulation of dopamine biosynthetic process |
| F | 1905627 | biological_process | regulation of serotonin biosynthetic process |
| G | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| G | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0005759 | cellular_component | mitochondrial matrix |
| G | 0005975 | biological_process | carbohydrate metabolic process |
| G | 0006066 | biological_process | alcohol metabolic process |
| G | 0006068 | biological_process | ethanol catabolic process |
| G | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase activity |
| G | 0009055 | molecular_function | electron transfer activity |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| G | 0018547 | molecular_function | nitroglycerin reductase activity |
| G | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| G | 0046185 | biological_process | aldehyde catabolic process |
| G | 0051287 | molecular_function | NAD binding |
| G | 0070062 | cellular_component | extracellular exosome |
| G | 0106435 | molecular_function | carboxylesterase activity |
| G | 1903179 | biological_process | regulation of dopamine biosynthetic process |
| G | 1905627 | biological_process | regulation of serotonin biosynthetic process |
| H | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| H | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005759 | cellular_component | mitochondrial matrix |
| H | 0005975 | biological_process | carbohydrate metabolic process |
| H | 0006066 | biological_process | alcohol metabolic process |
| H | 0006068 | biological_process | ethanol catabolic process |
| H | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase activity |
| H | 0009055 | molecular_function | electron transfer activity |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| H | 0018547 | molecular_function | nitroglycerin reductase activity |
| H | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| H | 0046185 | biological_process | aldehyde catabolic process |
| H | 0051287 | molecular_function | NAD binding |
| H | 0070062 | cellular_component | extracellular exosome |
| H | 0106435 | molecular_function | carboxylesterase activity |
| H | 1903179 | biological_process | regulation of dopamine biosynthetic process |
| H | 1905627 | biological_process | regulation of serotonin biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 601 |
| Chain | Residue |
| A | THR39 |
| A | VAL40 |
| A | ASP109 |
| A | GLN196 |
| A | HOH707 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 602 |
| Chain | Residue |
| B | GLN444 |
| D | PHE151 |
| A | TYR153 |
| A | ARG155 |
| B | ASN440 |
| B | SER443 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 603 |
| Chain | Residue |
| A | PHE18 |
| A | ASP98 |
| A | TYR101 |
| A | TYR203 |
| A | HOH712 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue GAI A 604 |
| Chain | Residue |
| A | GLU157 |
| A | PRO158 |
| A | VAL159 |
| B | TYR468 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue GAI A 605 |
| Chain | Residue |
| A | PHE459 |
| A | HOH756 |
| B | ASP147 |
| B | PHE150 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue 6ZE A 606 |
| Chain | Residue |
| A | PHE170 |
| A | MET174 |
| A | PHE296 |
| A | CYS301 |
| A | CYS302 |
| A | CYS303 |
| A | ASP457 |
| A | PHE459 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue NA B 601 |
| Chain | Residue |
| B | THR39 |
| B | VAL40 |
| B | ASP109 |
| B | GLN196 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 602 |
| Chain | Residue |
| A | ASN440 |
| A | SER443 |
| B | TYR153 |
| B | ARG155 |
| C | PHE151 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 603 |
| Chain | Residue |
| B | PHE151 |
| C | TYR153 |
| C | ARG155 |
| D | ASN440 |
| D | SER443 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue GAI B 604 |
| Chain | Residue |
| A | TYR468 |
| B | GLU157 |
| B | PRO158 |
| B | VAL159 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for residue 6ZE B 605 |
| Chain | Residue |
| B | PHE170 |
| B | MET174 |
| B | TRP177 |
| B | PHE296 |
| B | CYS301 |
| B | CYS302 |
| B | CYS303 |
| B | ASP457 |
| B | PHE459 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue NA C 601 |
| Chain | Residue |
| C | THR39 |
| C | VAL40 |
| C | ASP109 |
| C | GLN196 |
| C | HOH880 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue GAI C 602 |
| Chain | Residue |
| C | GLU157 |
| C | PRO158 |
| C | VAL159 |
| C | HOH882 |
| C | HOH884 |
| D | GLN447 |
| D | TYR468 |
| site_id | AD5 |
| Number of Residues | 10 |
| Details | binding site for residue 6ZE C 603 |
| Chain | Residue |
| C | VAL120 |
| C | MET124 |
| C | PHE170 |
| C | MET174 |
| C | PHE296 |
| C | CYS301 |
| C | CYS302 |
| C | CYS303 |
| C | ASP457 |
| C | PHE459 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue NA D 601 |
| Chain | Residue |
| D | THR39 |
| D | VAL40 |
| D | ASP109 |
| D | GLN196 |
| D | HOH795 |
| D | HOH832 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 602 |
| Chain | Residue |
| D | PHE18 |
| D | TYR101 |
| D | TYR203 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue GAI D 603 |
| Chain | Residue |
| C | PHE459 |
| D | ILE146 |
| D | ASP147 |
| D | PHE150 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue GAI D 604 |
| Chain | Residue |
| C | TYR468 |
| D | GLU157 |
| D | PRO158 |
| D | VAL159 |
| D | HOH737 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue GAI D 605 |
| Chain | Residue |
| D | PRO167 |
| D | TRP168 |
| D | ASN169 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue GAI D 606 |
| Chain | Residue |
| C | ASP147 |
| D | PHE459 |
| D | HOH826 |
| site_id | AE3 |
| Number of Residues | 12 |
| Details | binding site for residue 6ZE D 607 |
| Chain | Residue |
| D | MET124 |
| D | PHE170 |
| D | MET174 |
| D | TRP177 |
| D | GLU268 |
| D | PHE296 |
| D | CYS301 |
| D | CYS302 |
| D | CYS303 |
| D | ASP457 |
| D | PHE459 |
| D | PHE465 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue NA E 601 |
| Chain | Residue |
| E | THR39 |
| E | VAL40 |
| E | ASP109 |
| E | GLN196 |
| E | HOH718 |
| E | HOH847 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO E 602 |
| Chain | Residue |
| E | TYR153 |
| E | ARG155 |
| F | SER443 |
| H | PHE151 |
| site_id | AE6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO E 603 |
| Chain | Residue |
| E | PRO496 |
| G | ILE413 |
| site_id | AE7 |
| Number of Residues | 3 |
| Details | binding site for residue GAI E 604 |
| Chain | Residue |
| E | GLU157 |
| E | PRO158 |
| E | VAL159 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue GAI E 605 |
| Chain | Residue |
| E | ILE146 |
| E | ASP147 |
| E | PHE150 |
| F | PHE459 |
| site_id | AE9 |
| Number of Residues | 2 |
| Details | binding site for residue GAI E 606 |
| Chain | Residue |
| E | GLY225 |
| E | ALA230 |
| site_id | AF1 |
| Number of Residues | 10 |
| Details | binding site for residue 6ZE E 607 |
| Chain | Residue |
| E | VAL120 |
| E | PHE170 |
| E | MET174 |
| E | TRP177 |
| E | PHE296 |
| E | CYS301 |
| E | CYS302 |
| E | CYS303 |
| E | ASP457 |
| E | PHE459 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue NA F 601 |
| Chain | Residue |
| F | THR39 |
| F | VAL40 |
| F | ASP109 |
| F | GLN196 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO F 602 |
| Chain | Residue |
| E | ASN440 |
| E | SER443 |
| F | TYR153 |
| F | ARG155 |
| site_id | AF4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO F 603 |
| Chain | Residue |
| F | PHE18 |
| F | ASP98 |
| F | TYR203 |
| site_id | AF5 |
| Number of Residues | 3 |
| Details | binding site for residue GAI F 604 |
| Chain | Residue |
| F | GLU157 |
| F | PRO158 |
| F | VAL159 |
| site_id | AF6 |
| Number of Residues | 10 |
| Details | binding site for residue 6ZE F 605 |
| Chain | Residue |
| F | PHE170 |
| F | MET174 |
| F | TRP177 |
| F | PHE292 |
| F | PHE296 |
| F | CYS301 |
| F | CYS302 |
| F | CYS303 |
| F | ASP457 |
| F | PHE459 |
| site_id | AF7 |
| Number of Residues | 4 |
| Details | binding site for residue NA G 601 |
| Chain | Residue |
| G | THR39 |
| G | VAL40 |
| G | ASP109 |
| G | GLN196 |
| site_id | AF8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO G 602 |
| Chain | Residue |
| F | PHE151 |
| G | TYR153 |
| G | ARG155 |
| H | SER443 |
| site_id | AF9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO G 603 |
| Chain | Residue |
| E | GLN497 |
| G | TYR441 |
| G | GLN444 |
| G | ALA445 |
| G | HOH758 |
| G | HOH801 |
| site_id | AG1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO G 604 |
| Chain | Residue |
| G | ASN41 |
| G | THR44 |
| G | GLU46 |
| G | ILE48 |
| G | LEU108 |
| site_id | AG2 |
| Number of Residues | 6 |
| Details | binding site for residue GAI G 605 |
| Chain | Residue |
| G | GLU157 |
| G | PRO158 |
| G | VAL159 |
| G | HOH789 |
| G | HOH792 |
| H | TYR468 |
| site_id | AG3 |
| Number of Residues | 3 |
| Details | binding site for residue GAI G 606 |
| Chain | Residue |
| G | ASP147 |
| G | PHE150 |
| H | PHE459 |
| site_id | AG4 |
| Number of Residues | 2 |
| Details | binding site for residue GAI G 607 |
| Chain | Residue |
| G | TYR101 |
| G | TYR203 |
| site_id | AG5 |
| Number of Residues | 8 |
| Details | binding site for residue 6ZE G 608 |
| Chain | Residue |
| G | PHE170 |
| G | MET174 |
| G | PHE296 |
| G | CYS301 |
| G | CYS302 |
| G | CYS303 |
| G | ASP457 |
| G | PHE459 |
| site_id | AG6 |
| Number of Residues | 5 |
| Details | binding site for residue NA H 601 |
| Chain | Residue |
| H | THR39 |
| H | VAL40 |
| H | ASP109 |
| H | GLN196 |
| H | HOH728 |
| site_id | AG7 |
| Number of Residues | 6 |
| Details | binding site for residue GAI H 602 |
| Chain | Residue |
| G | TYR468 |
| H | GLU157 |
| H | PRO158 |
| H | VAL159 |
| H | HOH819 |
| H | HOH825 |
| site_id | AG8 |
| Number of Residues | 11 |
| Details | binding site for residue 6ZE H 603 |
| Chain | Residue |
| H | MET124 |
| H | PHE170 |
| H | LEU173 |
| H | MET174 |
| H | TRP177 |
| H | PHE296 |
| H | CYS301 |
| H | CYS302 |
| H | CYS303 |
| H | ASP457 |
| H | PHE459 |
Functional Information from PROSITE/UniProt
| site_id | PS00070 |
| Number of Residues | 12 |
| Details | ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FfNQGQCCCAGS |
| Chain | Residue | Details |
| A | PHE295-SER306 |
| site_id | PS00539 |
| Number of Residues | 6 |
| Details | PYROKININ Pyrokinins signature. FGPRLG |
| Chain | Residue | Details |
| A | PHE-9-GLY-4 |
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP |
| Chain | Residue | Details |
| A | LEU267-PRO274 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | GLU268 | |
| B | GLU268 | |
| C | GLU268 | |
| D | GLU268 | |
| E | GLU268 | |
| F | GLU268 | |
| G | GLU268 | |
| H | GLU268 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | ACT_SITE: Nucleophile |
| Chain | Residue | Details |
| A | CYS302 | |
| B | CYS302 | |
| C | CYS302 | |
| D | CYS302 | |
| E | CYS302 | |
| F | CYS302 | |
| G | CYS302 | |
| H | CYS302 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY245 | |
| B | GLY245 | |
| C | GLY245 | |
| D | GLY245 | |
| E | GLY245 | |
| F | GLY245 | |
| G | GLY245 | |
| H | GLY245 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | SITE: Transition state stabilizer => ECO:0000250|UniProtKB:P20000 |
| Chain | Residue | Details |
| A | ASN169 | |
| B | ASN169 | |
| C | ASN169 | |
| D | ASN169 | |
| E | ASN169 | |
| F | ASN169 | |
| G | ASN169 | |
| H | ASN169 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 72 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P47738 |
| Chain | Residue | Details |
| A | LYS35 | |
| B | LYS35 | |
| B | LYS56 | |
| B | LYS61 | |
| B | LYS142 | |
| B | LYS351 | |
| B | LYS366 | |
| B | LYS409 | |
| B | LYS411 | |
| B | LYS434 | |
| C | LYS35 | |
| A | LYS56 | |
| C | LYS56 | |
| C | LYS61 | |
| C | LYS142 | |
| C | LYS351 | |
| C | LYS366 | |
| C | LYS409 | |
| C | LYS411 | |
| C | LYS434 | |
| D | LYS35 | |
| D | LYS56 | |
| A | LYS61 | |
| D | LYS61 | |
| D | LYS142 | |
| D | LYS351 | |
| D | LYS366 | |
| D | LYS409 | |
| D | LYS411 | |
| D | LYS434 | |
| E | LYS35 | |
| E | LYS56 | |
| E | LYS61 | |
| A | LYS142 | |
| E | LYS142 | |
| E | LYS351 | |
| E | LYS366 | |
| E | LYS409 | |
| E | LYS411 | |
| E | LYS434 | |
| F | LYS35 | |
| F | LYS56 | |
| F | LYS61 | |
| F | LYS142 | |
| A | LYS351 | |
| F | LYS351 | |
| F | LYS366 | |
| F | LYS409 | |
| F | LYS411 | |
| F | LYS434 | |
| G | LYS35 | |
| G | LYS56 | |
| G | LYS61 | |
| G | LYS142 | |
| G | LYS351 | |
| A | LYS366 | |
| G | LYS366 | |
| G | LYS409 | |
| G | LYS411 | |
| G | LYS434 | |
| H | LYS35 | |
| H | LYS56 | |
| H | LYS61 | |
| H | LYS142 | |
| H | LYS351 | |
| H | LYS366 | |
| A | LYS409 | |
| H | LYS409 | |
| H | LYS411 | |
| H | LYS434 | |
| A | LYS411 | |
| A | LYS434 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 803 |
| Chain | Residue | Details |
| A | LYS192 | electrostatic stabiliser |
| A | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
| A | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
| A | GLU399 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 803 |
| Chain | Residue | Details |
| B | LYS192 | electrostatic stabiliser |
| B | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
| B | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
| B | GLU399 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 4 |
| Details | M-CSA 803 |
| Chain | Residue | Details |
| C | LYS192 | electrostatic stabiliser |
| C | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
| C | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
| C | GLU399 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 4 |
| Details | M-CSA 803 |
| Chain | Residue | Details |
| D | LYS192 | electrostatic stabiliser |
| D | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
| D | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
| D | GLU399 | electrostatic stabiliser |
| site_id | MCSA5 |
| Number of Residues | 4 |
| Details | M-CSA 803 |
| Chain | Residue | Details |
| E | LYS192 | electrostatic stabiliser |
| E | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
| E | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
| E | GLU399 | electrostatic stabiliser |
| site_id | MCSA6 |
| Number of Residues | 4 |
| Details | M-CSA 803 |
| Chain | Residue | Details |
| F | LYS192 | electrostatic stabiliser |
| F | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
| F | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
| F | GLU399 | electrostatic stabiliser |
| site_id | MCSA7 |
| Number of Residues | 4 |
| Details | M-CSA 803 |
| Chain | Residue | Details |
| G | LYS192 | electrostatic stabiliser |
| G | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
| G | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
| G | GLU399 | electrostatic stabiliser |
| site_id | MCSA8 |
| Number of Residues | 4 |
| Details | M-CSA 803 |
| Chain | Residue | Details |
| H | LYS192 | electrostatic stabiliser |
| H | GLU268 | electrostatic stabiliser, proton acceptor, proton donor |
| H | CYS302 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
| H | GLU399 | electrostatic stabiliser |
