5L0S
human POGLUT1 in complex with Factor VII EGF1 and UDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001756 | biological_process | somitogenesis |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0006486 | biological_process | protein glycosylation |
| A | 0006493 | biological_process | protein O-linked glycosylation |
| A | 0007369 | biological_process | gastrulation |
| A | 0008593 | biological_process | regulation of Notch signaling pathway |
| A | 0010470 | biological_process | regulation of gastrulation |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0018242 | biological_process | obsolete protein O-linked glycosylation via serine |
| A | 0035251 | molecular_function | UDP-glucosyltransferase activity |
| A | 0035252 | molecular_function | UDP-xylosyltransferase activity |
| A | 0045747 | biological_process | positive regulation of Notch signaling pathway |
| A | 0046527 | molecular_function | glucosyltransferase activity |
| A | 0048318 | biological_process | axial mesoderm development |
| A | 0048339 | biological_process | paraxial mesoderm development |
| A | 0060537 | biological_process | muscle tissue development |
| A | 0072359 | biological_process | circulatory system development |
| A | 0140561 | molecular_function | EGF-domain serine glucosyltransferase activity |
| A | 0140562 | molecular_function | EGF-domain serine xylosyltransferase activity |
| A | 0180059 | biological_process | protein O-linked glycosylation via glucose |
| A | 0180064 | biological_process | protein O-linked glycosylation via xylose |
| B | 0005509 | molecular_function | calcium ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00010 |
| Number of Residues | 12 |
| Details | ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CkDqlqsYiCfC |
| Chain | Residue | Details |
| B | CYS61-CYS72 |
| site_id | PS00022 |
| Number of Residues | 12 |
| Details | EGF_1 EGF-like domain signature 1. CfClpAfeGRnC |
| Chain | Residue | Details |
| B | CYS70-CYS81 |
| site_id | PS01187 |
| Number of Residues | 25 |
| Details | EGF_CA Calcium-binding EGF-like domain signature. DgDQCassp..........Cqnggs..CkDqlqsYiC |
| Chain | Residue | Details |
| B | ASP46-CYS70 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Region: {"description":"Interaction with the consensus sequence C-X-S-X-[PA]-C in peptide substrates","evidences":[{"source":"PubMed","id":"28775322","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"28775322","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28775322","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L0U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with the consensus sequence C-X-S-X-[PA]-C in peptide substrates","evidences":[{"source":"PubMed","id":"28775322","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28775322","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L0V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for S-112 for O-xylosylation"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"(3R)-3-hydroxyaspartate","evidences":[{"source":"PubMed","id":"3264725","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (Xyl...) serine; alternate","evidences":[{"source":"PubMed","id":"1904059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2129367","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21949356","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2511201","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (Fuc) serine","featureId":"CAR_000180","evidences":[{"source":"PubMed","id":"1904059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9023546","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
