5KZZ
Crystal structure of the xenopus Smoothened cysteine-rich domain (CRD) in its apo-form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0007224 | biological_process | smoothened signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue ACT A 201 |
| Chain | Residue |
| A | ASP77 |
| A | GLY118 |
| A | GLN121 |
| A | GLU149 |
| A | GLU154 |
| A | ZN202 |
| A | ZN203 |
| A | GOL207 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 202 |
| Chain | Residue |
| A | GLU154 |
| A | ACT201 |
| A | ZN203 |
| A | GOL207 |
| A | GLU149 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 203 |
| Chain | Residue |
| A | ASP77 |
| A | GLU149 |
| A | ACT201 |
| A | ZN202 |
| A | GOL207 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 204 |
| Chain | Residue |
| A | LYS47 |
| A | ASP73 |
| A | HOH366 |
| A | HOH369 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 205 |
| Chain | Residue |
| A | HIS76 |
| A | ASP93 |
| A | HOH365 |
| A | HOH370 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 206 |
| Chain | Residue |
| A | GLU74 |
| A | ASP138 |
| A | HOH302 |
| A | HOH354 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 207 |
| Chain | Residue |
| A | ASP73 |
| A | ASP77 |
| A | GLU149 |
| A | GLY150 |
| A | GLU154 |
| A | ACT201 |
| A | ZN202 |
| A | ZN203 |
| A | HOH315 |
| A | HOH377 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 208 |
| Chain | Residue |
| A | ALA88 |
| A | PRO89 |
| A | ARG90 |
| A | CYS91 |
| A | HOH333 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 209 |
| Chain | Residue |
| A | ILE50 |
| A | CYS51 |
| A | LEU52 |
| A | SER80 |
| A | HOH313 |
| A | HOH342 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27545348","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29804838","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D35","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"Cholesterol aspartate ester","evidences":[{"source":"UniProtKB","id":"Q99835","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
