5KZE

N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0008747	molecular_function	N-acetylneuraminate lyase activity
A	0016829	molecular_function	lyase activity
A	0019262	biological_process	N-acetylneuraminate catabolic process
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0008747	molecular_function	N-acetylneuraminate lyase activity
B	0016829	molecular_function	lyase activity
B	0019262	biological_process	N-acetylneuraminate catabolic process
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0008747	molecular_function	N-acetylneuraminate lyase activity
C	0016829	molecular_function	lyase activity
C	0019262	biological_process	N-acetylneuraminate catabolic process
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005975	biological_process	carbohydrate metabolic process
D	0008747	molecular_function	N-acetylneuraminate lyase activity
D	0016829	molecular_function	lyase activity
D	0019262	biological_process	N-acetylneuraminate catabolic process
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005975	biological_process	carbohydrate metabolic process
E	0008747	molecular_function	N-acetylneuraminate lyase activity
E	0016829	molecular_function	lyase activity
E	0019262	biological_process	N-acetylneuraminate catabolic process
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005975	biological_process	carbohydrate metabolic process
F	0008747	molecular_function	N-acetylneuraminate lyase activity
F	0016829	molecular_function	lyase activity
F	0019262	biological_process	N-acetylneuraminate catabolic process
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005975	biological_process	carbohydrate metabolic process
G	0008747	molecular_function	N-acetylneuraminate lyase activity
G	0016829	molecular_function	lyase activity
G	0019262	biological_process	N-acetylneuraminate catabolic process
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005975	biological_process	carbohydrate metabolic process
H	0008747	molecular_function	N-acetylneuraminate lyase activity
H	0016829	molecular_function	lyase activity
H	0019262	biological_process	N-acetylneuraminate catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 A 301

Chain	Residue
A	ALA11
A	GLY47
A	SER48
A	SER49
A	TYR137
A	LYS165

---

site_id	AC2
Number of Residues	5
Details	binding site for residue GOL A 302

Chain	Residue
A	HOH411
A	HOH427
A	ASP191
A	GLU192
A	SER208

---

site_id	AC3
Number of Residues	8
Details	binding site for residue SO4 B 301

Chain	Residue
B	ALA11
B	GLY47
B	SER48
B	SER49
B	TYR137
B	LYS165
B	HOH402
B	HOH417

---

site_id	AC4
Number of Residues	5
Details	binding site for residue GOL B 302

Chain	Residue
B	GLY189
B	PHE190
B	ASP191
B	GLU192
B	HOH401

---

site_id	AC5
Number of Residues	8
Details	binding site for residue SO4 C 301

Chain	Residue
C	ALA11
C	TYR44
C	GLY47
C	SER48
C	SER49
C	TYR137
C	LYS165
C	HOH496

---

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL C 302

Chain	Residue
C	SER49
C	GLU192
C	SER208
C	ILE251
C	TYR252

---

site_id	AC7
Number of Residues	8
Details	binding site for residue SO4 D 301

Chain	Residue
D	ALA11
D	GLY47
D	SER48
D	SER49
D	TYR137
D	LYS165
D	HOH421
D	HOH437

---

site_id	AC8
Number of Residues	4
Details	binding site for residue GOL D 302

Chain	Residue
D	PHE190
D	ASP191
D	GLU192
D	LEU247

---

site_id	AC9
Number of Residues	8
Details	binding site for residue SO4 E 301

Chain	Residue
E	ALA11
E	GLY47
E	SER48
E	SER49
E	TYR137
E	LYS165
E	HOH417
E	HOH505

---

site_id	AD1
Number of Residues	3
Details	binding site for residue GOL E 302

Chain	Residue
E	GLY189
E	LEU247
E	ILE251

---

site_id	AD2
Number of Residues	7
Details	binding site for residue SO4 F 301

Chain	Residue
F	ALA11
F	TYR44
F	GLY47
F	SER48
F	SER49
F	TYR137
F	LYS165

---

site_id	AD3
Number of Residues	6
Details	binding site for residue GOL F 302

Chain	Residue
F	PHE190
F	SER208
F	HOH401
F	HOH409
F	HOH463
F	HOH507

---

site_id	AD4
Number of Residues	8
Details	binding site for residue SO4 G 301

Chain	Residue
G	ALA11
G	TYR44
G	GLY47
G	SER48
G	SER49
G	TYR137
G	LYS165
G	HOH413

---

site_id	AD5
Number of Residues	3
Details	binding site for residue GOL G 302

Chain	Residue
G	GLU192
G	SER208
G	HOH456

---

site_id	AD6
Number of Residues	8
Details	binding site for residue SO4 H 301

Chain	Residue
H	ALA11
H	TYR44
H	GLY47
H	SER48
H	SER49
H	TYR137
H	LYS165
H	HOH415

---

site_id	AD7
Number of Residues	3
Details	binding site for residue GOL H 302

Chain	Residue
H	THR167
H	GLY189
H	GLU192

---

Functional Information from PROSITE/UniProt

site_id	PS00666
Number of Residues	31
Details	DHDPS_2 Dihydrodipicolinate synthase signature 2. YAIPdlTgvnIsieqfselfnhek.IvGVKYT

Chain	Residue	Details
A	TYR137-THR167

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_01237","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Schiff-base intermediate with substrate","evidences":[{"source":"HAMAP-Rule","id":"MF_01237","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23418011","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	56
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27943302","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5KZD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01237","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---