5KZD

N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus with bound sialic acid alditol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0008747	molecular_function	N-acetylneuraminate lyase activity
A	0016829	molecular_function	lyase activity
A	0019262	biological_process	N-acetylneuraminate catabolic process
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0008747	molecular_function	N-acetylneuraminate lyase activity
B	0016829	molecular_function	lyase activity
B	0019262	biological_process	N-acetylneuraminate catabolic process
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0008747	molecular_function	N-acetylneuraminate lyase activity
C	0016829	molecular_function	lyase activity
C	0019262	biological_process	N-acetylneuraminate catabolic process
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005975	biological_process	carbohydrate metabolic process
D	0008747	molecular_function	N-acetylneuraminate lyase activity
D	0016829	molecular_function	lyase activity
D	0019262	biological_process	N-acetylneuraminate catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue RCJ A 301

Chain	Residue
A	ALA11
A	ILE206
A	GLY207
A	SER208
A	ILE243
A	ILE251
A	TYR252
A	TYR44
A	GLY47
A	SER48
A	SER49
A	LYS165
A	GLY189
A	ASP191
A	GLU192

---

site_id	AC2
Number of Residues	15
Details	binding site for residue RCJ B 301

Chain	Residue
B	ALA11
B	TYR44
B	GLY47
B	SER48
B	SER49
B	LYS165
B	GLY189
B	ASP191
B	GLU192
B	ILE206
B	GLY207
B	SER208
B	LEU247
B	ILE251
B	TYR252

---

site_id	AC3
Number of Residues	14
Details	binding site for residue RCJ C 301

Chain	Residue
C	ALA11
C	TYR44
C	GLY47
C	SER48
C	SER49
C	TYR137
C	LYS165
C	GLY189
C	ASP191
C	GLU192
C	GLY207
C	SER208
C	ILE251
C	TYR252

---

site_id	AC4
Number of Residues	16
Details	binding site for residue RCJ D 301

Chain	Residue
D	ALA11
D	TYR44
D	GLY47
D	SER48
D	SER49
D	TYR137
D	LYS165
D	GLY189
D	ASP191
D	GLU192
D	ILE206
D	GLY207
D	SER208
D	LEU247
D	ILE251
D	TYR252

---

Functional Information from PROSITE/UniProt

site_id	PS00666
Number of Residues	31
Details	DHDPS_2 Dihydrodipicolinate synthase signature 2. YAIPdlTgvnIsieqfselfnhek.IvGVKYT

Chain	Residue	Details
A	TYR137-THR167

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_01237

Chain	Residue	Details
A	TYR137
B	TYR137
C	TYR137
D	TYR137

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Schiff-base intermediate with substrate => ECO:0000255|HAMAP-Rule:MF_01237, ECO:0000269|PubMed:23418011

Chain	Residue	Details
A	LYS165
B	LYS165
C	LYS165
D	LYS165

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	BINDING: BINDING => ECO:0000305|PubMed:27943302, ECO:0007744|PDB:5KZD

Chain	Residue	Details
A	SER48
B	ASP191
B	GLU192
B	SER208
C	SER48
C	SER49
C	GLY189
C	ASP191
C	GLU192
C	SER208
D	SER48
A	SER49
D	SER49
D	GLY189
D	ASP191
D	GLU192
D	SER208
A	TYR252
B	TYR252
C	TYR252
D	TYR252
A	GLY189
A	ASP191
A	GLU192
A	SER208
B	SER48
B	SER49
B	GLY189

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01237

Chain	Residue	Details
A	THR167
B	THR167
C	THR167
D	THR167

---