5KYO
Crystal Structure of CYP101J2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| B | 0020037 | molecular_function | heme binding |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004497 | molecular_function | monooxygenase activity |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| C | 0020037 | molecular_function | heme binding |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004497 | molecular_function | monooxygenase activity |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| D | 0020037 | molecular_function | heme binding |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0004497 | molecular_function | monooxygenase activity |
| E | 0005506 | molecular_function | iron ion binding |
| E | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| E | 0020037 | molecular_function | heme binding |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0004497 | molecular_function | monooxygenase activity |
| F | 0005506 | molecular_function | iron ion binding |
| F | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| F | 0020037 | molecular_function | heme binding |
| F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue HEM A 501 |
| Chain | Residue |
| A | ASN84 |
| A | SER299 |
| A | ARG301 |
| A | THR351 |
| A | PHE352 |
| A | HIS357 |
| A | CYS359 |
| A | PRO360 |
| A | GLY361 |
| A | LEU364 |
| A | ALA365 |
| A | LEU103 |
| A | HOH643 |
| A | HOH647 |
| A | HOH710 |
| A | HOH759 |
| A | HOH814 |
| A | HIS110 |
| A | VAL247 |
| A | GLY250 |
| A | GLY251 |
| A | THR254 |
| A | PHE291 |
| A | VAL297 |
| site_id | AC2 |
| Number of Residues | 26 |
| Details | binding site for residue HEM B 501 |
| Chain | Residue |
| B | ASN84 |
| B | LEU103 |
| B | HIS110 |
| B | VAL247 |
| B | GLY250 |
| B | GLY251 |
| B | THR254 |
| B | MET258 |
| B | PHE291 |
| B | VAL297 |
| B | SER299 |
| B | ARG301 |
| B | THR351 |
| B | PHE352 |
| B | GLY353 |
| B | HIS357 |
| B | CYS359 |
| B | PRO360 |
| B | GLY361 |
| B | LEU364 |
| B | ALA365 |
| B | HOH671 |
| B | HOH688 |
| B | HOH752 |
| B | HOH760 |
| B | HOH801 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | binding site for residue HEM C 501 |
| Chain | Residue |
| C | ASN84 |
| C | LEU103 |
| C | HIS110 |
| C | LEU121 |
| C | VAL247 |
| C | GLY250 |
| C | GLY251 |
| C | THR254 |
| C | VAL255 |
| C | VAL297 |
| C | SER299 |
| C | ARG301 |
| C | THR351 |
| C | HIS357 |
| C | CYS359 |
| C | PRO360 |
| C | GLY361 |
| C | ALA365 |
| C | HOH644 |
| C | HOH659 |
| C | HOH695 |
| C | HOH734 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | binding site for residue HEM D 501 |
| Chain | Residue |
| D | ASN84 |
| D | LEU103 |
| D | HIS110 |
| D | LEU117 |
| D | VAL247 |
| D | GLY250 |
| D | GLY251 |
| D | THR254 |
| D | MET258 |
| D | SER299 |
| D | ARG301 |
| D | THR351 |
| D | PHE352 |
| D | GLY353 |
| D | HIS357 |
| D | CYS359 |
| D | PRO360 |
| D | LEU364 |
| D | HOH641 |
| D | HOH659 |
| D | HOH677 |
| site_id | AC5 |
| Number of Residues | 24 |
| Details | binding site for residue HEM E 501 |
| Chain | Residue |
| E | THR254 |
| E | MET258 |
| E | PHE291 |
| E | SER299 |
| E | ARG301 |
| E | THR351 |
| E | PHE352 |
| E | GLY353 |
| E | HIS357 |
| E | CYS359 |
| E | PRO360 |
| E | GLY361 |
| E | LEU364 |
| E | ALA365 |
| E | HOH629 |
| E | HOH680 |
| E | HOH687 |
| E | HOH709 |
| E | ASN84 |
| E | LEU103 |
| E | HIS110 |
| E | VAL247 |
| E | GLY250 |
| E | GLY251 |
| site_id | AC6 |
| Number of Residues | 23 |
| Details | binding site for residue HEM F 501 |
| Chain | Residue |
| F | ASN84 |
| F | LEU103 |
| F | HIS110 |
| F | VAL247 |
| F | GLY250 |
| F | GLY251 |
| F | THR254 |
| F | VAL255 |
| F | VAL297 |
| F | SER299 |
| F | ARG301 |
| F | THR351 |
| F | PHE352 |
| F | GLY353 |
| F | HIS357 |
| F | CYS359 |
| F | PRO360 |
| F | GLY361 |
| F | ALA365 |
| F | HOH615 |
| F | HOH629 |
| F | HOH672 |
| F | HOH714 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGkGSHTCPG |
| Chain | Residue | Details |
| A | PHE352-GLY361 |
