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5KYJ

Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0006629biological_processlipid metabolic process
B0003677molecular_functionDNA binding
B0003707molecular_functionnuclear steroid receptor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
B0008270molecular_functionzinc ion binding
E0003677molecular_functionDNA binding
E0004879molecular_functionnuclear receptor activity
E0006629biological_processlipid metabolic process
F0003677molecular_functionDNA binding
F0003707molecular_functionnuclear steroid receptor activity
F0005634cellular_componentnucleus
F0006355biological_processregulation of DNA-templated transcription
F0008270molecular_functionzinc ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues12
Detailsbinding site for residue 6Y8 A 501
ChainResidue
APHE271
AHIS435
AGLN438
ATRP457
ATHR272
AALA275
AGLU281
AMET312
ATHR316
AARG319
APHE329
ALEU330

site_idAC2
Number of Residues14
Detailsbinding site for residue 6Y8 E 501
ChainResidue
EPHE271
ETHR272
ELEU274
EALA275
EMET312
ETHR316
EARG319
EPHE329
ELEU330
ELEU345
EPHE349
EHIS435
EGLN438
ETRP457

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000269|PubMed:20159957
ChainResidueDetails
ALYS410
ALYS448
ELYS410
ELYS448

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PDB entries from 2024-07-10

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