5KYA

Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006629	biological_process	lipid metabolic process
B	0003677	molecular_function	DNA binding
B	0003707	molecular_function	nuclear steroid receptor activity
B	0005634	cellular_component	nucleus
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008270	molecular_function	zinc ion binding
E	0003677	molecular_function	DNA binding
E	0004879	molecular_function	nuclear receptor activity
E	0006629	biological_process	lipid metabolic process
F	0003677	molecular_function	DNA binding
F	0003707	molecular_function	nuclear steroid receptor activity
F	0005634	cellular_component	nucleus
F	0006355	biological_process	regulation of DNA-templated transcription
F	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue 6Y4 A 501

Chain	Residue
A	PHE268
A	LEU345
A	HIS435
A	GLN438
A	PHE271
A	THR272
A	LEU274
A	MET312
A	THR316
A	ARG319
A	PHE329
A	LEU330

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site_id	AC2
Number of Residues	12
Details	binding site for residue 6Y4 E 501

Chain	Residue
E	PHE268
E	PHE271
E	THR272
E	LEU274
E	MET312
E	THR316
E	PHE329
E	LEU330
E	LEU345
E	HIS435
E	GLN438
E	LEU449

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"20159957","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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