5KWF

Joint X-ray Neutron Structure of Cholesterol Oxidase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004769	molecular_function	steroid delta-isomerase activity
A	0005576	cellular_component	extracellular region
A	0006707	biological_process	cholesterol catabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016853	molecular_function	isomerase activity
A	0016995	molecular_function	cholesterol oxidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	41
Details	binding site for residue FAD A 601

Chain	Residue
A	GLY17
A	ARG110
A	GLY111
A	GLY114
A	GLY115
A	ASN119
A	GLY120
A	GLY121
A	MET122
A	ILE218
A	HIS248
A	GLY19
A	VAL250
A	GLY288
A	ALA289
A	GLY290
A	TYR446
A	HIS447
A	ASP474
A	GLY475
A	ASN485
A	PRO486
A	TYR20
A	PHE487
A	ILE490
A	HOH746
A	DOD765
A	DOD766
A	HOH775
A	HOH801
A	DOD833
A	DOD836
A	DOD873
A	GLY21
A	DOD887
A	DOD922
A	LEU39
A	GLU40
A	MET41
A	TYR107
A	GLY109

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Functional Information from PROSITE/UniProt

site_id	PS00623
Number of Residues	24
Details	GMC_OXRED_1 GMC oxidoreductases signature 1. GRgVGGGSlVNggmAvePkrsyfE

Chain	Residue	Details
A	GLY109-GLU132

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000305|PubMed:10194345

Chain	Residue	Details
A	GLU361
A	HIS447

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site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING: BINDING => ECO:0007744|PDB:1B4V

Chain	Residue	Details
A	TYR20
A	GLU40
A	GLY115
A	ASN119
A	VAL250
A	GLY475
A	PHE487

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0007744|PDB:1IJH

Chain	Residue	Details
A	TYR446

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