5KVV
Structure of Malate Dehydrogenase in complex with NADH from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006107 | biological_process | oxaloacetate metabolic process |
| A | 0006108 | biological_process | malate metabolic process |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016615 | molecular_function | malate dehydrogenase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019674 | biological_process | NAD+ metabolic process |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006107 | biological_process | oxaloacetate metabolic process |
| B | 0006108 | biological_process | malate metabolic process |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016615 | molecular_function | malate dehydrogenase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019674 | biological_process | NAD+ metabolic process |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | binding site for residue NAI A 401 |
| Chain | Residue |
| A | GLY12 |
| A | ALA90 |
| A | ARG91 |
| A | PRO92 |
| A | ILE109 |
| A | GLN113 |
| A | THR130 |
| A | GLY131 |
| A | ASN132 |
| A | LEU156 |
| A | HIS188 |
| A | GLY15 |
| A | ALA243 |
| A | TRS403 |
| A | HOH502 |
| A | HOH515 |
| A | HOH526 |
| A | HOH532 |
| A | HOH541 |
| A | HOH561 |
| A | HOH570 |
| A | HOH580 |
| A | GLN16 |
| A | HOH608 |
| A | HOH622 |
| A | HOH642 |
| A | HOH672 |
| A | ILE17 |
| A | LEU42 |
| A | GLU43 |
| A | ILE44 |
| A | VAL88 |
| A | GLY89 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | SER273 |
| A | TYR274 |
| A | SER297 |
| A | GLY298 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue TRS A 403 |
| Chain | Residue |
| A | ARG93 |
| A | ASN132 |
| A | ARG163 |
| A | HIS188 |
| A | NAI401 |
| site_id | AC4 |
| Number of Residues | 32 |
| Details | binding site for residue NAI B 401 |
| Chain | Residue |
| B | GLY12 |
| B | GLY15 |
| B | GLN16 |
| B | ILE17 |
| B | LEU42 |
| B | GLU43 |
| B | ILE44 |
| B | VAL88 |
| B | GLY89 |
| B | ALA90 |
| B | ARG91 |
| B | PRO92 |
| B | GLN113 |
| B | THR130 |
| B | GLY131 |
| B | ASN132 |
| B | LEU156 |
| B | LEU159 |
| B | HIS188 |
| B | SER239 |
| B | ALA243 |
| B | SO4403 |
| B | HOH507 |
| B | HOH521 |
| B | HOH531 |
| B | HOH533 |
| B | HOH535 |
| B | HOH547 |
| B | HOH549 |
| B | HOH554 |
| B | HOH560 |
| B | HOH562 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 402 |
| Chain | Residue |
| A | GLU278 |
| A | GLY279 |
| A | ARG320 |
| A | HOH550 |
| B | ALA314 |
| B | HOH587 |
| B | HOH637 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| B | ASN132 |
| B | LEU159 |
| B | ARG163 |
| B | HIS188 |
| B | GLY228 |
| B | SER239 |
| B | NAI401 |
| B | HOH530 |
| B | HOH541 |
| B | HOH608 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 404 |
| Chain | Residue |
| B | ARG93 |
| B | ARG99 |
| B | SER189 |
| B | ALA190 |
| B | HOH555 |
Functional Information from PROSITE/UniProt
| site_id | PS00068 |
| Number of Residues | 13 |
| Details | MDH Malate dehydrogenase active site signature. LTRLDhnRAisqL |
| Chain | Residue | Details |
| A | LEU156-LEU168 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_01517","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01517","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
