Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 401 |
| Chain | Residue |
| A | LYS77 |
| A | ARG80 |
| A | ARG155 |
| A | ASN189 |
| A | VAL192 |
| A | HOH511 |
| A | HOH536 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | ASN238 |
| A | EDO414 |
| A | HOH537 |
| A | ARG191 |
| A | LYS198 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | LYS279 |
| A | ARG280 |
| A | ARG283 |
| A | EDO413 |
| B | HOH521 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 404 |
| Chain | Residue |
| A | LYS102 |
| B | LYS74 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 405 |
| Chain | Residue |
| A | LYS74 |
| A | LYS76 |
| A | LYS77 |
| A | HOH511 |
| A | HOH588 |
| B | ARG107 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 406 |
| Chain | Residue |
| A | SER277 |
| A | ARG278 |
| A | HOH504 |
| A | HOH516 |
| A | HOH545 |
| B | SER277 |
| B | ARG278 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 407 |
| Chain | Residue |
| A | GLY48 |
| A | LYS49 |
| A | TYR50 |
| A | 6XK425 |
| A | HOH582 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 408 |
| Chain | Residue |
| A | HIS276 |
| A | SER277 |
| A | LYS279 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 409 |
| Chain | Residue |
| A | GLU32 |
| A | TRP33 |
| B | TYR196 |
| B | HIS234 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 410 |
| Chain | Residue |
| A | ASP237 |
| A | ASN238 |
| A | HOH535 |
| A | HOH542 |
| A | HOH590 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 411 |
| Chain | Residue |
| A | PRO6 |
| A | ARG8 |
| A | GLY185 |
| A | MET208 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 412 |
| Chain | Residue |
| A | ARG47 |
| A | LYS74 |
| A | LYS76 |
| B | LYS75 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 413 |
| Chain | Residue |
| A | ARG280 |
| A | SO4403 |
| B | ASP253 |
| B | ARG306 |
| B | SER311 |
| B | HOH577 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 414 |
| Chain | Residue |
| A | VAL190 |
| A | LYS198 |
| A | LEU202 |
| A | ASN238 |
| A | SO4402 |
| A | HOH512 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 415 |
| Chain | Residue |
| A | LYS75 |
| B | LYS74 |
| B | LYS75 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 416 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 417 |
| Chain | Residue |
| A | GLN36 |
| A | TYR39 |
| A | ASP103 |
| A | EDO424 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 418 |
| Chain | Residue |
| A | TRP24 |
| A | ASP25 |
| A | TYR26 |
| A | GLU27 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 419 |
| Chain | Residue |
| A | THR17 |
| A | HIS18 |
| A | ARG19 |
| A | GLN40 |
| A | EDO424 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 420 |
| Chain | Residue |
| A | ASN117 |
| A | THR119 |
| A | ASP165 |
| A | HIS166 |
| A | GLU167 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 421 |
| Chain | Residue |
| A | ARG47 |
| A | LYS75 |
| A | LYS76 |
| B | LYS75 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 422 |
| Chain | Residue |
| A | LYS142 |
| A | EDO423 |
| A | PRO92 |
| A | ASN93 |
| A | GLU139 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 423 |
| Chain | Residue |
| A | GLY91 |
| A | PRO92 |
| A | ASN93 |
| A | ARG172 |
| A | EDO422 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 424 |
| Chain | Residue |
| A | ARG21 |
| A | LEU41 |
| A | EDO417 |
| A | EDO419 |
| A | HOH507 |
| site_id | AE7 |
| Number of Residues | 15 |
| Details | binding site for residue 6XK A 425 |
| Chain | Residue |
| A | ARG47 |
| A | GLY48 |
| A | SER51 |
| A | VAL53 |
| A | VAL66 |
| A | LYS68 |
| A | PHE113 |
| A | GLU114 |
| A | VAL116 |
| A | ASN118 |
| A | MET163 |
| A | ASP175 |
| A | SO4407 |
| A | HOH513 |
| A | HOH530 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 401 |
| Chain | Residue |
| B | LYS77 |
| B | ARG80 |
| B | ARG155 |
| B | ASN189 |
| B | VAL192 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| B | LYS229 |
| B | HIS234 |
| B | ARG244 |
| B | HOH512 |
| site_id | AF1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| B | TRP33 |
| B | LYS102 |
| B | HOH526 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 404 |
| Chain | Residue |
| A | HOH548 |
| B | LYS279 |
| B | ARG280 |
| B | ARG283 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 405 |
| Chain | Residue |
| B | LYS158 |
| B | HIS160 |
| B | SER194 |
| B | TYR196 |
| site_id | AF4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 406 |
| Chain | Residue |
| B | PRO4 |
| B | GLU187 |
| B | ASP205 |
| B | TYR206 |
| B | GLN207 |
| B | MET208 |
| site_id | AF5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 407 |
| Chain | Residue |
| B | GLU27 |
| B | LYS44 |
| B | LEU45 |
| B | GLY46 |
| B | ARG47 |
| B | EDO412 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 408 |
| Chain | Residue |
| B | PHE232 |
| B | ARG244 |
| B | VAL248 |
| B | HOH512 |
| site_id | AF7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 409 |
| Chain | Residue |
| B | LYS49 |
| B | 6XK416 |
| B | HOH569 |
| site_id | AF8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 410 |
| Chain | Residue |
| B | HIS276 |
| B | SER277 |
| B | LYS279 |
| site_id | AF9 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 411 |
| Chain | Residue |
| A | ARG195 |
| A | HIS236 |
| B | HIS29 |
| B | VAL30 |
| B | VAL31 |
| B | GLU32 |
| B | GLU86 |
| B | HOH590 |
| site_id | AG1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 412 |
| Chain | Residue |
| B | ASP25 |
| B | TYR26 |
| B | GLU27 |
| B | LYS44 |
| B | EDO407 |
| site_id | AG2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 413 |
| Chain | Residue |
| B | GLN36 |
| B | TYR39 |
| B | ASP103 |
| site_id | AG3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 414 |
| Chain | Residue |
| B | LEU203 |
| B | ASN238 |
| site_id | AG4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 415 |
| Chain | Residue |
| B | TYR12 |
| B | THR13 |
| B | ASP14 |
| B | VAL15 |
| site_id | AG5 |
| Number of Residues | 17 |
| Details | binding site for residue 6XK B 416 |
| Chain | Residue |
| B | ARG47 |
| B | GLY48 |
| B | SER51 |
| B | VAL53 |
| B | VAL66 |
| B | LYS68 |
| B | ILE95 |
| B | PHE113 |
| B | GLU114 |
| B | HIS115 |
| B | VAL116 |
| B | MET163 |
| B | ASP175 |
| B | EDO409 |
| B | HOH501 |
| B | HOH504 |
| B | HOH567 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK |
| Chain | Residue | Details |
| A | LEU45-LYS68 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI |
| Chain | Residue | Details |
| A | ILE152-ILE164 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Region: {"description":"Interaction with beta subunit","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 285 |
| Details | Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
