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5KTX

CREBBP bromodomain in complex with Cpd59 ((S)-1-(3-((2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)ethanone)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004402molecular_functionhistone acetyltransferase activity
A0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue 6XH A 1201
ChainResidue
ALEU1109
ASER1179
AGLU1186
AHOH1316
AHOH1394
AHOH1400
APRO1110
ALEU1120
AILE1122
ATRP1165
AASN1168
AARG1173
AVAL1174
APHE1177

site_idAC2
Number of Residues5
Detailsbinding site for residue EDO A 1202
ChainResidue
AGLN1104
AASP1105
AGLU1107
AHOH1313
AHOH1363

site_idAC3
Number of Residues7
Detailsbinding site for residue EDO A 1203
ChainResidue
AARG1091
AMET1095
APRO1096
AASP1124
AHOH1324
AHOH1369
AHOH1385

site_idAC4
Number of Residues5
Detailsbinding site for residue DMS A 1204
ChainResidue
ATRP1151
ALYS1170
ATHR1171
AMET1193
AHOH1360

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY
ChainResidueDetails
ASER1108-TYR1167

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues107
DetailsDomain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues46
DetailsRegion: {"description":"Interaction with histone","evidences":[{"source":"PubMed","id":"24361270","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues18
DetailsRegion: {"description":"Interaction with ASF1A","evidences":[{"source":"PubMed","id":"24616510","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

242842

PDB entries from 2025-10-08

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