5KTX

CREBBP bromodomain in complex with Cpd59 ((S)-1-(3-((2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)ethanone)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 6XH A 1201

Chain	Residue
A	LEU1109
A	SER1179
A	GLU1186
A	HOH1316
A	HOH1394
A	HOH1400
A	PRO1110
A	LEU1120
A	ILE1122
A	TRP1165
A	ASN1168
A	ARG1173
A	VAL1174
A	PHE1177

---

site_id	AC2
Number of Residues	5
Details	binding site for residue EDO A 1202

Chain	Residue
A	GLN1104
A	ASP1105
A	GLU1107
A	HOH1313
A	HOH1363

---

site_id	AC3
Number of Residues	7
Details	binding site for residue EDO A 1203

Chain	Residue
A	ARG1091
A	MET1095
A	PRO1096
A	ASP1124
A	HOH1324
A	HOH1369
A	HOH1385

---

site_id	AC4
Number of Residues	5
Details	binding site for residue DMS A 1204

Chain	Residue
A	TRP1151
A	LYS1170
A	THR1171
A	MET1193
A	HOH1360

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY

Chain	Residue	Details
A	SER1108-TYR1167

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	107
Details	Domain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	46
Details	Region: {"description":"Interaction with histone","evidences":[{"source":"PubMed","id":"24361270","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Region: {"description":"Interaction with ASF1A","evidences":[{"source":"PubMed","id":"24616510","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---