5KRO
Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the Methyl(phenyl)amino-substituted Estrogen, (8R,9S,13S,14S,17S)-13-methyl-17-(methyl(phenyl)amino)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue 6WW A 601 |
| Chain | Residue |
| A | MET343 |
| A | GLU353 |
| A | LEU387 |
| A | ARG394 |
| A | MET421 |
| A | ILE424 |
| A | HIS524 |
| A | LEU525 |
| A | HOH734 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue 6WW B 601 |
| Chain | Residue |
| B | GLU353 |
| B | LEU387 |
| B | ARG394 |
| B | MET421 |
| B | HIS524 |
| B | LEU525 |
| B | HOH742 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| C | SER699 | |
| D | SER699 | |
| Chain | Residue | Details |
| A | ILE358-LEU378 | |
| A | ARG394-VAL418 | |
| B | ILE358-LEU378 | |
| B | ARG394-VAL418 | |
| Chain | Residue | Details |
| A | ALA340 | |
| B | ALA340 | |
| Chain | Residue | Details |
| A | SER433 | |
| B | SER433 | |
