5KRM
Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the A-CD ring estrogen, (1S,7aS)-5-(2,5-difluoro-4-hydroxyphenyl)-7a-methyl-2,3,3a,4,7,7a-hexahydro-1H-inden-1-ol
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue 6WU A 601 |
| Chain | Residue |
| A | LEU346 |
| A | HOH736 |
| A | LEU349 |
| A | ALA350 |
| A | GLU353 |
| A | LEU387 |
| A | MET388 |
| A | ARG394 |
| A | GLY521 |
| A | HIS524 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue 6WU B 601 |
| Chain | Residue |
| B | LEU346 |
| B | LEU349 |
| B | ALA350 |
| B | GLU353 |
| B | LEU387 |
| B | MET388 |
| B | ARG394 |
| B | GLY521 |
| B | HIS524 |
| B | HOH728 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| C | SER699 | |
| D | SER699 | |
| Chain | Residue | Details |
| A | ILE358-LEU378 | |
| A | ARG394-VAL418 | |
| B | ILE358-LEU378 | |
| B | ARG394-VAL418 | |
| Chain | Residue | Details |
| A | ALA340 | |
| B | ALA340 | |
| Chain | Residue | Details |
| A | SER433 | |
| B | SER433 | |
