5KQR
Structure of NS5 methyltransferase from Zika virus bound to S-adenosylmethionine
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue SAM A 301 |
| Chain | Residue |
| A | SER56 |
| A | HIS110 |
| A | GLU111 |
| A | VAL130 |
| A | ASP131 |
| A | VAL132 |
| A | PHE133 |
| A | ASP146 |
| A | HOH449 |
| A | HOH469 |
| A | HOH528 |
| A | GLY58 |
| A | HOH606 |
| A | GLY81 |
| A | CYS82 |
| A | GLY83 |
| A | GLY86 |
| A | TRP87 |
| A | THR104 |
| A | LYS105 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 302 |
| Chain | Residue |
| A | ARG37 |
| A | ARG41 |
| A | SER56 |
| A | ARG57 |
| A | ARG84 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 303 |
| Chain | Residue |
| A | GLY148 |
| A | HOH641 |
| A | HOH679 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 |
| Chain | Residue | Details |
| A | LYS61 | |
| A | ASP146 | |
| A | LYS182 | |
| A | GLU218 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27866982 |
| Chain | Residue | Details |
| A | LYS13 | |
| A | GLU149 | |
| A | ARG213 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982 |
| Chain | Residue | Details |
| A | SER56 | |
| A | THR104 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 |
| Chain | Residue | Details |
| A | GLY86 | |
| A | TRP87 | |
| A | LYS105 | |
| A | ASP131 | |
| A | VAL132 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 |
| Chain | Residue | Details |
| A | HIS110 | |
| A | GLU111 | |
| A | ASP146 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| A | ILE147 | |
| A | TYR220 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 7 |
| Details | SITE: mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| A | LYS13 | |
| A | ASN17 | |
| A | PHE24 | |
| A | LYS28 | |
| A | SER150 | |
| A | ARG213 | |
| A | SER215 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | SITE: mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| A | LEU16 | |
| A | MET19 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | SITE: Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| A | LYS61 | |
| A | LYS182 | |
| A | GLU218 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | SITE: Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| A | ASP146 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P03314 |
| Chain | Residue | Details |
| A | SER56 |
