5KP7

Crystal Structure of the Curacin Biosynthetic Pathway HMG Synthase in Complex with Holo Donor-ACP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004421	molecular_function	hydroxymethylglutaryl-CoA synthase activity
A	0006084	biological_process	acetyl-CoA metabolic process
A	0010142	biological_process	farnesyl diphosphate biosynthetic process, mevalonate pathway
A	0016746	molecular_function	acyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 501

Chain	Residue
A	SER353
A	LYS410
A	LYS415

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site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 502

Chain	Residue
A	TYR231
A	VAL235
A	ARG320
A	HOH840

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site_id	AC3
Number of Residues	12
Details	binding site for residue PNS B 100

Chain	Residue
A	MET39
A	PHE163
A	PRO166
A	SER167
A	SER216
A	MET256
B	SER39
B	ARG42
B	HOH206
B	HOH208
A	ARG33
A	LEU37

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