5KOI

Crystal Structure of a Possible Enoyl-(acyl-carrier-protein) Reductase from Brucella melitensis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
B	0000166	molecular_function	nucleotide binding
B	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
C	0000166	molecular_function	nucleotide binding
C	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
D	0000166	molecular_function	nucleotide binding
D	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
E	0000166	molecular_function	nucleotide binding
E	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0006633	biological_process	fatty acid biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
F	0000166	molecular_function	nucleotide binding
F	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F	0006629	biological_process	lipid metabolic process
F	0006631	biological_process	fatty acid metabolic process
F	0006633	biological_process	fatty acid biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
G	0000166	molecular_function	nucleotide binding
G	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G	0006629	biological_process	lipid metabolic process
G	0006631	biological_process	fatty acid metabolic process
G	0006633	biological_process	fatty acid biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
H	0000166	molecular_function	nucleotide binding
H	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H	0006629	biological_process	lipid metabolic process
H	0006631	biological_process	fatty acid metabolic process
H	0006633	biological_process	fatty acid biosynthetic process
H	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	30
Details	binding site for residue NAD A 300

Chain	Residue
A	GLY14
A	ALA92
A	ILE93
A	GLY94
A	ILE120
A	LEU145
A	THR146
A	LYS164
A	ALA190
A	GLY191
A	PRO192
A	VAL15
A	VAL193
A	THR195
A	LEU196
A	ALA197
A	HOH425
A	HOH430
A	HOH475
A	HOH484
A	HOH502
A	HOH519
A	ALA16
A	HOH544
A	SER20
A	LEU21
A	GLN41
A	CYS64
A	ASP65
A	VAL66

---

site_id	AC2
Number of Residues	26
Details	binding site for residue NAD B 300

Chain	Residue
B	GLY14
B	VAL15
B	ALA16
B	SER20
B	LEU21
B	GLN41
B	CYS64
B	ASP65
B	VAL66
B	ALA92
B	ILE93
B	GLY94
B	LEU145
B	THR146
B	LYS164
B	ALA190
B	GLY191
B	PRO192
B	VAL193
B	HOH411
B	HOH419
B	HOH452
B	HOH459
B	HOH460
B	HOH485
B	HOH554

---

site_id	AC3
Number of Residues	29
Details	binding site for residue NAD C 300

Chain	Residue
C	GLY14
C	VAL15
C	ALA16
C	SER20
C	LEU21
C	GLN41
C	LEU45
C	CYS64
C	ASP65
C	VAL66
C	ALA92
C	ILE93
C	GLY94
C	PHE95
C	ILE120
C	LEU145
C	THR146
C	LYS164
C	ALA190
C	GLY191
C	PRO192
C	VAL193
C	HOH401
C	HOH402
C	HOH423
C	HOH427
C	HOH442
C	HOH524
C	HOH532

---

site_id	AC4
Number of Residues	29
Details	binding site for residue NAD D 300

Chain	Residue
D	LEU145
D	THR146
D	LYS164
D	ALA190
D	GLY191
D	PRO192
D	VAL193
D	HOH407
D	HOH415
D	HOH417
D	HOH443
D	HOH447
D	HOH504
D	HOH508
D	HOH539
D	GLY14
D	VAL15
D	ALA16
D	SER20
D	LEU21
D	GLN41
D	LEU45
D	CYS64
D	ASP65
D	VAL66
D	ALA92
D	ILE93
D	GLY94
D	ILE120

---

site_id	AC5
Number of Residues	31
Details	binding site for residue NAD E 300

Chain	Residue
E	GLY14
E	VAL15
E	ALA16
E	SER20
E	LEU21
E	GLN41
E	CYS64
E	ASP65
E	VAL66
E	ALA92
E	ILE93
E	GLY94
E	ILE120
E	LEU145
E	THR146
E	LYS164
E	ALA190
E	GLY191
E	PRO192
E	VAL193
E	THR195
E	LEU196
E	ALA197
E	HOH429
E	HOH441
E	HOH501
E	HOH507
E	HOH516
E	HOH520
E	HOH533
E	HOH543

---

site_id	AC6
Number of Residues	25
Details	binding site for residue NAD F 300

Chain	Residue
F	GLY14
F	VAL15
F	ALA16
F	SER20
F	LEU21
F	GLN41
F	LEU45
F	CYS64
F	ASP65
F	VAL66
F	ALA92
F	ILE93
F	GLY94
F	ILE120
F	LEU145
F	THR146
F	LYS164
F	ALA190
F	GLY191
F	PRO192
F	VAL193
F	HOH402
F	HOH474
F	HOH480
F	HOH488

---

site_id	AC7
Number of Residues	29
Details	binding site for residue NAD G 300

Chain	Residue
G	GLY14
G	VAL15
G	ALA16
G	SER20
G	LEU21
G	GLN41
G	LEU45
G	CYS64
G	ASP65
G	VAL66
G	ALA92
G	ILE93
G	GLY94
G	ILE120
G	LEU145
G	THR146
G	LYS164
G	ALA190
G	GLY191
G	PRO192
G	VAL193
G	HOH403
G	HOH404
G	HOH407
G	HOH410
G	HOH463
G	HOH483
G	HOH498
G	HOH528

---

site_id	AC8
Number of Residues	28
Details	binding site for residue NAD H 300

Chain	Residue
H	GLY14
H	VAL15
H	ALA16
H	LEU21
H	GLN41
H	LEU45
H	CYS64
H	ASP65
H	VAL66
H	ALA92
H	ILE93
H	GLY94
H	LEU145
H	THR146
H	TYR147
H	LYS164
H	ALA190
H	GLY191
H	PRO192
H	VAL193
H	HOH401
H	HOH403
H	HOH405
H	HOH416
H	HOH509
H	HOH513
H	HOH530
H	HOH564

---