5KO3

Structure of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	CYS191
A	CYS194
A	CYS226
A	CYS228

---

site_id	AC2
Number of Residues	3
Details	binding site for residue ACT A 402

Chain	Residue
A	TYR84
A	LYS87
A	ACT405

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ACT A 403

Chain	Residue
A	LYS285
A	HOH509
A	VAL101
A	ARG283

---

site_id	AC4
Number of Residues	2
Details	binding site for residue ACT A 404

Chain	Residue
A	LYS299
A	HOH586

---

site_id	AC5
Number of Residues	5
Details	binding site for residue ACT A 405

Chain	Residue
A	ALA132
A	HIS135
A	LYS139
A	ASP147
A	ACT402

---

site_id	AC6
Number of Residues	3
Details	binding site for residue ACT A 406

Chain	Residue
A	GLN270
A	LYS291
A	ASP293

---

site_id	AC7
Number of Residues	6
Details	binding site for residue ACT A 407

Chain	Residue
A	LYS124
A	ASP125
A	ILE126
A	VAL276
A	HOH519
A	HOH522

---

site_id	AC8
Number of Residues	5
Details	binding site for residue ACT A 408

Chain	Residue
A	VAL75
A	ASP76
A	ARG82
A	ALA154
A	ASN157

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	37
Details	Zinc finger: {"description":"C4-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"For PL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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