5KMH

Structure of CavAb in complex with Br-verapamil

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001518	cellular_component	voltage-gated sodium channel complex
A	0005216	molecular_function	monoatomic ion channel activity
A	0005248	molecular_function	voltage-gated sodium channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0086010	biological_process	membrane depolarization during action potential
B	0001518	cellular_component	voltage-gated sodium channel complex
B	0005216	molecular_function	monoatomic ion channel activity
B	0005248	molecular_function	voltage-gated sodium channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0086010	biological_process	membrane depolarization during action potential
C	0001518	cellular_component	voltage-gated sodium channel complex
C	0005216	molecular_function	monoatomic ion channel activity
C	0005248	molecular_function	voltage-gated sodium channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0055085	biological_process	transmembrane transport
C	0086010	biological_process	membrane depolarization during action potential
D	0001518	cellular_component	voltage-gated sodium channel complex
D	0005216	molecular_function	monoatomic ion channel activity
D	0005248	molecular_function	voltage-gated sodium channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0035725	biological_process	sodium ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0055085	biological_process	transmembrane transport
D	0086010	biological_process	membrane depolarization during action potential

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue CA A 1301

Chain	Residue
A	ASP1178

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site_id	AC2
Number of Residues	8
Details	binding site for residue MC3 A 1303

Chain	Residue
A	PHE1141
A	THR1162
A	GLY1164
A	GLU1165
A	PHE1171
C	MET1188
C	TRP1195
C	PHE1203

---

site_id	AC3
Number of Residues	4
Details	binding site for residue MC3 A 1304

Chain	Residue
A	TRP1195
A	ILE1199
B	GLY1164
B	PHE1171

---

site_id	AC4
Number of Residues	4
Details	binding site for residue PX6 A 1305

Chain	Residue
A	LEU1151
A	TYR1191
A	TYR1193
A	ALA1194

---

site_id	AC5
Number of Residues	3
Details	binding site for residue MC3 A 1306

Chain	Residue
A	THR1033
A	SER1034
C	LEU1163

---

site_id	AC6
Number of Residues	3
Details	binding site for residue PX6 B 1301

Chain	Residue
B	TYR1191
B	TYR1193
D	ILE1097

---

site_id	AC7
Number of Residues	2
Details	binding site for residue MC3 B 1302

Chain	Residue
B	LEU1031
B	PHE1037

---

site_id	AC8
Number of Residues	4
Details	binding site for residue PX6 C 1301

Chain	Residue
C	PHE1152
C	TYR1191
C	TYR1193
C	ALA1194

---

site_id	AC9
Number of Residues	4
Details	binding site for residue 6U8 C 1302

Chain	Residue
A	MET1174
C	THR1206
D	MET1174
D	THR1206

---

site_id	AD1
Number of Residues	1
Details	binding site for residue CA D 1301

Chain	Residue
D	ASP1178

---

site_id	AD2
Number of Residues	4
Details	binding site for residue MC3 D 1302

Chain	Residue
B	TRP1195
B	ILE1199
D	GLY1164
D	PHE1171

---

site_id	AD3
Number of Residues	5
Details	binding site for residue PX6 D 1303

Chain	Residue
C	ILE1097
D	LEU1151
D	PHE1152
D	TYR1191
D	ALA1194

---

site_id	AD4
Number of Residues	5
Details	binding site for residue MC3 D 1304

Chain	Residue
B	THR1162
B	LEU1163
B	GLY1164
D	SER1034
D	THR1036

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