5KKA
E. coli malate dehydrogenase with the inhibitor 6DHNAD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006096 | biological_process | glycolytic process |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006108 | biological_process | malate metabolic process |
| A | 0006113 | biological_process | fermentation |
| A | 0009061 | biological_process | anaerobic respiration |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016615 | molecular_function | malate dehydrogenase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0019898 | cellular_component | extrinsic component of membrane |
| A | 0030060 | molecular_function | L-malate dehydrogenase activity |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006096 | biological_process | glycolytic process |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006108 | biological_process | malate metabolic process |
| B | 0006113 | biological_process | fermentation |
| B | 0009061 | biological_process | anaerobic respiration |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016615 | molecular_function | malate dehydrogenase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0019898 | cellular_component | extrinsic component of membrane |
| B | 0030060 | molecular_function | L-malate dehydrogenase activity |
| B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | binding site for residue 6V0 A 401 |
| Chain | Residue |
| A | ALA9 |
| A | GLY78 |
| A | ASN94 |
| A | ILE97 |
| A | ASN100 |
| A | LEU101 |
| A | ILE117 |
| A | ASN119 |
| A | VAL121 |
| A | VAL146 |
| A | HIS177 |
| A | GLY10 |
| A | ALA223 |
| A | THR224 |
| A | MET227 |
| A | HOH509 |
| A | HOH538 |
| A | HOH548 |
| A | HOH560 |
| A | HOH589 |
| A | HOH612 |
| A | HOH625 |
| A | GLY11 |
| A | HOH675 |
| A | ILE12 |
| A | TYR33 |
| A | ASP34 |
| A | ILE35 |
| A | SER76 |
| A | ALA77 |
| site_id | AC2 |
| Number of Residues | 30 |
| Details | binding site for residue 6V0 B 401 |
| Chain | Residue |
| B | GLY7 |
| B | GLY10 |
| B | GLY11 |
| B | ILE12 |
| B | TYR33 |
| B | ASP34 |
| B | ILE35 |
| B | SER76 |
| B | ALA77 |
| B | GLY78 |
| B | ILE97 |
| B | ASN100 |
| B | LEU101 |
| B | ILE117 |
| B | ASN119 |
| B | VAL121 |
| B | VAL146 |
| B | HIS177 |
| B | ALA223 |
| B | THR224 |
| B | MET227 |
| B | HOH518 |
| B | HOH532 |
| B | HOH538 |
| B | HOH553 |
| B | HOH569 |
| B | HOH575 |
| B | HOH594 |
| B | HOH605 |
| B | HOH653 |
Functional Information from PROSITE/UniProt
| site_id | PS00068 |
| Number of Residues | 13 |
| Details | MDH Malate dehydrogenase active site signature. VTTLDiiRSntfV |
| Chain | Residue | Details |
| A | VAL146-VAL158 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01516, ECO:0000305|PubMed:11389141 |
| Chain | Residue | Details |
| A | HIS177 | |
| B | HIS177 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01516, ECO:0000269|PubMed:11389141, ECO:0000269|PubMed:8331658 |
| Chain | Residue | Details |
| A | ASN94 | |
| A | ILE117 | |
| A | MET227 | |
| B | GLY7 | |
| B | ASP34 | |
| B | ASN94 | |
| B | ILE117 | |
| B | MET227 | |
| A | GLY7 | |
| A | ASP34 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01516, ECO:0000305|PubMed:1507230, ECO:0000305|PubMed:8331658 |
| Chain | Residue | Details |
| B | ASN119 | |
| B | ARG153 | |
| A | ARG81 | |
| A | ARG87 | |
| A | ASN119 | |
| A | ARG153 | |
| B | ARG81 | |
| B | ARG87 |
