5KKA
E. coli malate dehydrogenase with the inhibitor 6DHNAD
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006096 | biological_process | glycolytic process |
A | 0006099 | biological_process | tricarboxylic acid cycle |
A | 0006108 | biological_process | malate metabolic process |
A | 0006113 | biological_process | fermentation |
A | 0009061 | biological_process | anaerobic respiration |
A | 0016020 | cellular_component | membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016615 | molecular_function | malate dehydrogenase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0019752 | biological_process | carboxylic acid metabolic process |
A | 0019898 | cellular_component | extrinsic component of membrane |
A | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
A | 0042803 | molecular_function | protein homodimerization activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006096 | biological_process | glycolytic process |
B | 0006099 | biological_process | tricarboxylic acid cycle |
B | 0006108 | biological_process | malate metabolic process |
B | 0006113 | biological_process | fermentation |
B | 0009061 | biological_process | anaerobic respiration |
B | 0016020 | cellular_component | membrane |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016615 | molecular_function | malate dehydrogenase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0019752 | biological_process | carboxylic acid metabolic process |
B | 0019898 | cellular_component | extrinsic component of membrane |
B | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 30 |
Details | binding site for residue 6V0 A 401 |
Chain | Residue |
A | ALA9 |
A | GLY78 |
A | ASN94 |
A | ILE97 |
A | ASN100 |
A | LEU101 |
A | ILE117 |
A | ASN119 |
A | VAL121 |
A | VAL146 |
A | HIS177 |
A | GLY10 |
A | ALA223 |
A | THR224 |
A | MET227 |
A | HOH509 |
A | HOH538 |
A | HOH548 |
A | HOH560 |
A | HOH589 |
A | HOH612 |
A | HOH625 |
A | GLY11 |
A | HOH675 |
A | ILE12 |
A | TYR33 |
A | ASP34 |
A | ILE35 |
A | SER76 |
A | ALA77 |
site_id | AC2 |
Number of Residues | 30 |
Details | binding site for residue 6V0 B 401 |
Chain | Residue |
B | GLY7 |
B | GLY10 |
B | GLY11 |
B | ILE12 |
B | TYR33 |
B | ASP34 |
B | ILE35 |
B | SER76 |
B | ALA77 |
B | GLY78 |
B | ILE97 |
B | ASN100 |
B | LEU101 |
B | ILE117 |
B | ASN119 |
B | VAL121 |
B | VAL146 |
B | HIS177 |
B | ALA223 |
B | THR224 |
B | MET227 |
B | HOH518 |
B | HOH532 |
B | HOH538 |
B | HOH553 |
B | HOH569 |
B | HOH575 |
B | HOH594 |
B | HOH605 |
B | HOH653 |
Functional Information from PROSITE/UniProt
site_id | PS00068 |
Number of Residues | 13 |
Details | MDH Malate dehydrogenase active site signature. VTTLDiiRSntfV |
Chain | Residue | Details |
A | VAL146-VAL158 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01516, ECO:0000305|PubMed:11389141 |
Chain | Residue | Details |
A | HIS177 | |
B | HIS177 |
site_id | SWS_FT_FI2 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01516, ECO:0000269|PubMed:11389141, ECO:0000269|PubMed:8331658 |
Chain | Residue | Details |
A | GLY7 | |
B | MET227 | |
A | ASP34 | |
A | ASN94 | |
A | ILE117 | |
A | MET227 | |
B | GLY7 | |
B | ASP34 | |
B | ASN94 | |
B | ILE117 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01516, ECO:0000305|PubMed:1507230, ECO:0000305|PubMed:8331658 |
Chain | Residue | Details |
A | ARG81 | |
A | ARG87 | |
A | ASN119 | |
A | ARG153 | |
B | ARG81 | |
B | ARG87 | |
B | ASN119 | |
B | ARG153 |