5KK8

Crystal structure of Nucleoside Diphosphate Kinase from Schistosoma mansoni in complex with ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0005524	molecular_function	ATP binding
A	0006166	biological_process	purine ribonucleoside salvage
A	0006183	biological_process	GTP biosynthetic process
A	0006228	biological_process	UTP biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0009202	biological_process	deoxyribonucleoside triphosphate biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0032261	biological_process	purine nucleotide salvage
A	0034214	biological_process	protein hexamerization
A	0042802	molecular_function	identical protein binding
A	0043531	molecular_function	ADP binding
B	0000166	molecular_function	nucleotide binding
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0005524	molecular_function	ATP binding
B	0006166	biological_process	purine ribonucleoside salvage
B	0006183	biological_process	GTP biosynthetic process
B	0006228	biological_process	UTP biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0009202	biological_process	deoxyribonucleoside triphosphate biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0032261	biological_process	purine nucleotide salvage
B	0034214	biological_process	protein hexamerization
B	0042802	molecular_function	identical protein binding
B	0043531	molecular_function	ADP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue ADP A 201

Chain	Residue
A	LYS9
A	LEU52
A	LEU61
A	THR91
A	ARG102
A	VAL109
A	ASN112
A	HOH307
A	HOH312

---

site_id	AC2
Number of Residues	8
Details	binding site for residue ADP B 201

Chain	Residue
B	LYS9
B	PHE57
B	LEU61
B	ARG85
B	THR91
B	VAL109
B	ASN112
B	HOH325

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	262
Details	Domain: {"description":"NDPK-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00706","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Pros-phosphohistidine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00706","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00706","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31103556","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5KK8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---