5KK8
Crystal structure of Nucleoside Diphosphate Kinase from Schistosoma mansoni in complex with ADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006183 | biological_process | GTP biosynthetic process |
| A | 0006228 | biological_process | UTP biosynthetic process |
| A | 0006241 | biological_process | CTP biosynthetic process |
| A | 0009202 | biological_process | deoxyribonucleoside triphosphate biosynthetic process |
| A | 0032261 | biological_process | purine nucleotide salvage |
| A | 0034214 | biological_process | protein hexamerization |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043531 | molecular_function | ADP binding |
| B | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006183 | biological_process | GTP biosynthetic process |
| B | 0006228 | biological_process | UTP biosynthetic process |
| B | 0006241 | biological_process | CTP biosynthetic process |
| B | 0009202 | biological_process | deoxyribonucleoside triphosphate biosynthetic process |
| B | 0032261 | biological_process | purine nucleotide salvage |
| B | 0034214 | biological_process | protein hexamerization |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043531 | molecular_function | ADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue ADP A 201 |
| Chain | Residue |
| A | LYS9 |
| A | LEU52 |
| A | LEU61 |
| A | THR91 |
| A | ARG102 |
| A | VAL109 |
| A | ASN112 |
| A | HOH307 |
| A | HOH312 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue ADP B 201 |
| Chain | Residue |
| B | LYS9 |
| B | PHE57 |
| B | LEU61 |
| B | ARG85 |
| B | THR91 |
| B | VAL109 |
| B | ASN112 |
| B | HOH325 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 262 |
| Details | Domain: {"description":"NDPK-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00706","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Pros-phosphohistidine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00706","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00706","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31103556","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5KK8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
