Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5KHM

The first BET bromodomain of BRD4 bound to compound 13 in a bivalent manner

Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue XNH A 201
ChainResidue
APRO82
BPRO82
BPHE83
BLEU94
BCYS136
BTYR139
BASN140
BASP145
BILE146
BHOH310
APHE83
ALEU94
AASN140
AASP145
AILE146
AGOL202
AHOH304
BTRP81

site_idAC2
Number of Residues5
Detailsbinding site for residue GOL A 202
ChainResidue
AASP145
AXNH201
AHOH307
BLEU92
BHOH307

site_idAC3
Number of Residues7
Detailsbinding site for residue GOL B 201
ChainResidue
BILE100
BILE101
BLYS102
BTHR103
BASN135
BILE138
BHOH351

site_idAC4
Number of Residues3
Detailsbinding site for residue GOL B 202
ChainResidue
BASN116
BHOH327
BHOH362

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140
BASN140

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS99
ALYS99

221051

PDB entries from 2024-06-12

PDB statisticsPDBj update infoContact PDBjnumon