Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 401 |
| Chain | Residue |
| A | ILE133 |
| A | ASP170 |
| A | ASP234 |
| A | GLY238 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 402 |
| Chain | Residue |
| A | 6SL420 |
| A | GLU89 |
| A | LEU93 |
| A | ILE185 |
| A | ASP186 |
| A | PHE187 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | ARG136 |
| A | ALA138 |
| A | LEU139 |
| A | GLN140 |
| A | LEU143 |
| A | HOH521 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | ARG221 |
| A | SER222 |
| A | VAL225 |
| A | ARG278 |
| A | PRO279 |
| A | HOH514 |
| A | HOH559 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | PHE100 |
| A | GLU153 |
| A | ASN160 |
| A | GLN264 |
| A | ARG268 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | GLU35 |
| A | VAL40 |
| A | HIS68 |
| A | HOH535 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 407 |
| Chain | Residue |
| A | ASP114 |
| A | LEU193 |
| A | EDO419 |
| A | HOH563 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 408 |
| Chain | Residue |
| A | ASP170 |
| A | GLU171 |
| A | TYR207 |
| A | ILE240 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 409 |
| Chain | Residue |
| A | GLU181 |
| A | GLN252 |
| A | VAL253 |
| A | PHE254 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 410 |
| Chain | Residue |
| A | LYS169 |
| A | GLU171 |
| A | THR204 |
| A | HOH532 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 411 |
| Chain | Residue |
| A | GLY99 |
| A | ARG250 |
| A | GLY251 |
| A | GLN252 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 412 |
| Chain | Residue |
| A | GLU262 |
| A | HIS265 |
| A | HIS287 |
| A | PRO288 |
| A | EDO416 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 413 |
| Chain | Residue |
| A | GLU142 |
| A | ARG145 |
| A | HOH520 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 414 |
| Chain | Residue |
| A | LEU43 |
| A | HIS219 |
| A | ARG221 |
| A | SER222 |
| A | PRO275 |
| A | EDO418 |
| site_id | AD6 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 415 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 416 |
| Chain | Residue |
| A | TRP269 |
| A | GLU283 |
| A | ASN286 |
| A | HIS287 |
| A | PRO288 |
| A | EDO412 |
| A | HOH543 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 417 |
| Chain | Residue |
| A | HIS265 |
| A | TRP269 |
| A | HOH561 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 418 |
| Chain | Residue |
| A | TYR53 |
| A | LEU193 |
| A | LYS194 |
| A | GLY220 |
| A | ARG221 |
| A | EDO414 |
| A | HOH542 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 419 |
| Chain | Residue |
| A | EDO407 |
| A | HOH529 |
| site_id | AE2 |
| Number of Residues | 9 |
| Details | binding site for residue 6SL A 420 |
| Chain | Residue |
| A | PHE49 |
| A | ALA65 |
| A | LYS67 |
| A | GLU121 |
| A | LEU174 |
| A | ILE185 |
| A | ASP186 |
| A | EDO402 |
| A | HOH570 |
| site_id | AE3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 421 |
| Chain | Residue |
| A | HOH501 |
| A | HOH537 |
| A | HOH557 |
| A | ARG156 |
| A | ARG258 |
| A | SER261 |
| A | PHE281 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 422 |
| Chain | Residue |
| A | ASP108 |
| A | TRP109 |
| A | HOH524 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGGFGSVYsGirvsdnlp..........VAIK |
| Chain | Residue | Details |
| A | LEU44-LYS67 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDIKdeNILI |
| Chain | Residue | Details |
| A | VAL163-ILE175 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ASP167 | |
| Chain | Residue | Details |
| A | LEU44 | |
| Chain | Residue | Details |
| A | LYS67 | |
| A | GLU121 | |
| A | ASP128 | |
| Chain | Residue | Details |
| A | SER98 | |
| A | SER261 | |
