5KFZ

Human DNA polymerase eta-DNA ternary complex: reaction first with 1 mM Mn2+ for 1800s then with 5 mM Mn2+ for 60s at 14 degree

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003684	molecular_function	damaged DNA binding
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue MN A 501

Chain	Residue
A	ASP13
A	MET14
A	ASP115
A	DTP505
A	DPO506
A	MN508
P	DA9

---

site_id	AC2
Number of Residues	8
Details	binding site for residue GOL A 502

Chain	Residue
A	SER248
A	GLY276
A	HOH618
A	HOH644
A	HOH670
A	HOH692
A	ARG24
A	PRO244

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 503

Chain	Residue
A	GLU94
A	ALA95
A	GLU98
A	ARG303
A	HOH647
A	HOH681
A	HOH690

---

site_id	AC4
Number of Residues	9
Details	binding site for residue GOL A 504

Chain	Residue
A	ASN26
A	HIS28
A	GLY271
A	GLU273
A	TYR274
A	GLU277
A	HOH603
A	HOH605
A	HOH695

---

site_id	AC5
Number of Residues	33
Details	binding site for residue DTP A 505

Chain	Residue
A	ASP13
A	MET14
A	ASP15
A	CYS16
A	PHE17
A	PHE18
A	ILE48
A	ALA49
A	TYR52
A	ARG55
A	ARG61
A	ILE114
A	ASP115
A	LYS231
A	MN501
A	DPO506
A	MN508
A	HOH601
A	HOH625
A	HOH652
A	HOH678
A	HOH768
P	DT8
P	DA9
P	MN101
P	HOH604
P	HOH607
P	HOH614
P	HOH615
P	HOH620
T	DT3
T	DT4
T	DA5

---

site_id	AC6
Number of Residues	18
Details	binding site for residue DPO A 506

Chain	Residue
A	ASP13
A	MET14
A	ASP15
A	CYS16
A	PHE17
A	TYR52
A	ARG55
A	ARG61
A	ASP115
A	LYS231
A	MN501
A	DTP505
A	HOH625
A	HOH652
A	HOH678
A	HOH768
P	DA9
P	MN101

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO A 507

Chain	Residue
A	ASP13
A	LYS224
A	GLY228
A	LYS231
A	HOH768
A	HOH800
A	HOH872

---

site_id	AC8
Number of Residues	8
Details	binding site for residue MN A 508

Chain	Residue
A	ASP13
A	ASP115
A	GLU116
A	MN501
A	DTP505
P	DT8
P	DA9
P	HOH614

---

site_id	AC9
Number of Residues	8
Details	binding site for residue MN P 101

Chain	Residue
A	DPO506
A	HOH601
A	HOH652
A	HOH768
P	DA9
P	HOH604
A	ARG61
A	DTP505

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:27284197, ECO:0007744|PDB:5KFO

Chain	Residue	Details
A	ASP13
A	MET14
A	ASP115
A	GLU116

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:27284197

Chain	Residue	Details
A	ARG61

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