5KDW
IMPa metallopeptidase from Pseudomonas aeruginosa
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0015628 | biological_process | protein secretion by the type II secretion system |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030163 | biological_process | protein catabolic process |
| A | 0043952 | biological_process | protein transport by the Sec complex |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1903237 | biological_process | negative regulation of leukocyte tethering or rolling |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0015628 | biological_process | protein secretion by the type II secretion system |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030163 | biological_process | protein catabolic process |
| B | 0043952 | biological_process | protein transport by the Sec complex |
| B | 0046872 | molecular_function | metal ion binding |
| B | 1903237 | biological_process | negative regulation of leukocyte tethering or rolling |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1001 |
| Chain | Residue |
| A | LEU353 |
| A | ASN357 |
| A | GLN361 |
| A | LEU363 |
| A | GLY410 |
| A | VAL412 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 1002 |
| Chain | Residue |
| A | ASN900 |
| A | ARG901 |
| A | THR902 |
| A | HOH1220 |
| A | HOH1411 |
| A | HOH1438 |
| A | ASP740 |
| A | THR741 |
| A | VAL743 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1003 |
| Chain | Residue |
| A | GLU439 |
| A | SER466 |
| A | ARG468 |
| A | SER515 |
| A | LYS542 |
| A | VAL543 |
| A | THR544 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1004 |
| Chain | Residue |
| A | ASP795 |
| A | LEU910 |
| A | EDO1015 |
| A | HOH1151 |
| A | HOH1388 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1005 |
| Chain | Residue |
| A | LYS826 |
| A | GLY832 |
| A | THR833 |
| A | TYR834 |
| A | HOH1298 |
| B | ASN252 |
| B | HOH1248 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1006 |
| Chain | Residue |
| A | TYR710 |
| A | TYR766 |
| A | ARG875 |
| A | HOH1522 |
| A | HOH1568 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1007 |
| Chain | Residue |
| A | ALA355 |
| A | TYR356 |
| A | LYS359 |
| A | GLN361 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1008 |
| Chain | Residue |
| A | GLN496 |
| A | GLN668 |
| A | TYR669 |
| A | HOH1236 |
| A | HOH1379 |
| A | HOH1626 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1009 |
| Chain | Residue |
| A | ASN750 |
| A | TRP920 |
| A | HOH1169 |
| A | HOH1383 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1010 |
| Chain | Residue |
| A | GLY168 |
| A | ASP169 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1011 |
| Chain | Residue |
| A | GLN549 |
| A | PRO550 |
| A | PHE551 |
| A | ASP566 |
| A | PHE567 |
| A | HOH1156 |
| A | HOH1563 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 1012 |
| Chain | Residue |
| A | SER476 |
| A | LEU477 |
| A | ALA478 |
| A | LYS509 |
| A | VAL529 |
| A | SER531 |
| A | HOH1321 |
| A | HOH1765 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1013 |
| Chain | Residue |
| A | VAL185 |
| A | ASP186 |
| A | HOH1283 |
| A | HOH1391 |
| A | HOH1524 |
| A | HOH1795 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1014 |
| Chain | Residue |
| A | ALA794 |
| A | ASP795 |
| A | ASN798 |
| A | ASP799 |
| A | PRO800 |
| A | EDO1015 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1015 |
| Chain | Residue |
| A | PRO800 |
| A | TYR905 |
| A | EDO1004 |
| A | EDO1014 |
| A | HOH1284 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1016 |
| Chain | Residue |
| A | TYR792 |
| A | LEU796 |
| A | TYR897 |
| A | HOH1919 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1017 |
| Chain | Residue |
| A | ARG866 |
| A | PHE869 |
| A | ILE874 |
| A | THR876 |
| A | HOH1729 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1018 |
| Chain | Residue |
| A | LYS219 |
| A | HOH1149 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1019 |
| Chain | Residue |
| A | LEU796 |
| A | LYS797 |
| A | LEU860 |
| A | HOH1102 |
| A | GLU642 |
| site_id | AE2 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 1020 |
| Chain | Residue |
| A | TRP254 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1021 |
| Chain | Residue |
| A | HIS725 |
| A | TRP728 |
| A | ARG732 |
| A | HOH1145 |
| A | HOH1165 |
| A | HOH1434 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 1022 |
| Chain | Residue |
| A | HIS696 |
| A | HIS700 |
| A | GLU716 |
| A | TYR776 |
| A | HOH1576 |
| site_id | AE5 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 A 1023 |
| Chain | Residue |
| A | TRP692 |
| A | ASP739 |
| A | ARG742 |
| A | HOH1219 |
| A | HOH1264 |
| A | HOH1367 |
| A | HOH1403 |
| A | HOH1407 |
| site_id | AE6 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 1024 |
| Chain | Residue |
| A | SER286 |
| A | SER287 |
| A | PO41025 |
| A | HOH1105 |
| A | HOH1239 |
| A | HOH1792 |
| B | ARG429 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 1025 |
| Chain | Residue |
| A | ARG283 |
| A | PRO285 |
| A | SER286 |
| A | PO41024 |
| A | HOH1611 |
| site_id | AE8 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 1026 |
| Chain | Residue |
| A | GLN73 |
| A | ASP111 |
| A | ASN112 |
| A | GLY368 |
| A | THR369 |
| A | THR370 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 1001 |
| Chain | Residue |
| B | ASN357 |
| B | GLN361 |
| B | LEU363 |
| B | GLY410 |
| B | VAL412 |
| site_id | AF1 |
| Number of Residues | 9 |
| Details | binding site for residue EDO B 1002 |
| Chain | Residue |
| B | ASP740 |
| B | THR741 |
| B | VAL743 |
| B | ASN900 |
| B | ARG901 |
| B | THR902 |
| B | HOH1377 |
| B | HOH1474 |
| B | HOH1510 |
| site_id | AF2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 1003 |
| Chain | Residue |
| B | TRP254 |
| B | TYR274 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 1004 |
| Chain | Residue |
| B | ALA355 |
| B | LYS359 |
| B | GLN361 |
| B | HOH1154 |
| site_id | AF4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 1005 |
| Chain | Residue |
| B | ASP795 |
| B | VAL908 |
| B | HOH1480 |
| site_id | AF5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1006 |
| Chain | Residue |
| B | GLN496 |
| B | GLN668 |
| B | TYR669 |
| B | HOH1112 |
| B | HOH1287 |
| B | HOH1423 |
| site_id | AF6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 1007 |
| Chain | Residue |
| B | GLU439 |
| B | SER466 |
| B | ARG468 |
| B | SER515 |
| B | LYS542 |
| B | VAL543 |
| B | THR544 |
| site_id | AF7 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 1008 |
| Chain | Residue |
| B | SER476 |
| B | LEU477 |
| B | ALA478 |
| B | LYS509 |
| B | VAL529 |
| B | SER531 |
| B | HOH1375 |
| B | HOH1595 |
| site_id | AF8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 1009 |
| Chain | Residue |
| B | GLN308 |
| B | ASP312 |
| B | HOH1227 |
| site_id | AF9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1010 |
| Chain | Residue |
| B | TYR710 |
| B | ALA763 |
| B | TYR766 |
| B | ARG875 |
| B | HOH1416 |
| B | HOH1567 |
| site_id | AG1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 1011 |
| Chain | Residue |
| B | GLU642 |
| B | ARG646 |
| B | LEU796 |
| B | LYS797 |
| B | LEU860 |
| site_id | AG2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 1012 |
| Chain | Residue |
| B | ALA305 |
| B | GLN309 |
| B | ARG345 |
| site_id | AG3 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 1013 |
| Chain | Residue |
| B | GLY423 |
| B | SER424 |
| B | TYR425 |
| B | ALA426 |
| B | ASP577 |
| B | LYS591 |
| B | EDO1020 |
| B | HOH1271 |
| site_id | AG4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1014 |
| Chain | Residue |
| B | VAL185 |
| B | ASP186 |
| B | THR251 |
| B | HOH1381 |
| B | HOH1432 |
| B | HOH1451 |
| site_id | AG5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 1015 |
| Chain | Residue |
| B | ARG387 |
| B | TYR388 |
| B | GLU421 |
| B | HOH1128 |
| site_id | AG6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 1016 |
| Chain | Residue |
| B | PRO389 |
| B | ASP395 |
| B | HOH1149 |
| B | HOH1210 |
| B | HOH1258 |
| site_id | AG7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 1017 |
| Chain | Residue |
| B | THR833 |
| B | TYR834 |
| B | HOH1239 |
| B | HOH1673 |
| B | HOH1674 |
| site_id | AG8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 1018 |
| Chain | Residue |
| B | PRO550 |
| B | PHE551 |
| B | ASP566 |
| B | PHE567 |
| B | ALA570 |
| B | HOH1110 |
| B | HOH1168 |
| site_id | AG9 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 1019 |
| Chain | Residue |
| B | LEU762 |
| B | ARG866 |
| B | PHE869 |
| B | ILE874 |
| B | ARG875 |
| B | THR876 |
| B | GLN881 |
| B | HOH1104 |
| site_id | AH1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 1020 |
| Chain | Residue |
| A | HOH1792 |
| B | GLY427 |
| B | GLN428 |
| B | EDO1013 |
| B | HOH1296 |
| site_id | AH2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 1021 |
| Chain | Residue |
| B | LYS219 |
| B | HOH1545 |
| site_id | AH3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 1022 |
| Chain | Residue |
| B | HIS696 |
| B | HIS700 |
| B | GLU716 |
| B | TYR776 |
| B | HOH1302 |
| site_id | AH4 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 B 1023 |
| Chain | Residue |
| B | GLN73 |
| B | ARG76 |
| B | ASP111 |
| B | ASN112 |
| B | GLY368 |
| B | THR369 |
| B | THR370 |
| B | HOH1574 |
| site_id | AH5 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 B 1024 |
| Chain | Residue |
| B | TRP692 |
| B | ASP739 |
| B | ARG742 |
| B | HOH1299 |
| B | HOH1379 |
| B | HOH1410 |
| B | HOH1460 |
| B | HOH1512 |
| site_id | AH6 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 B 1025 |
| Chain | Residue |
| A | ARG429 |
| A | HOH1435 |
| B | ARG283 |
| B | PRO285 |
| B | SER286 |
| B | SER287 |
| B | HOH1155 |
| B | HOH1187 |
| B | HOH1221 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. GESHELGHNL |
| Chain | Residue | Details |
| A | GLY693-LEU702 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 688 |
| Details | Domain: {"description":"Peptidase M60","evidences":[{"source":"PROSITE-ProRule","id":"PRU01060","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
