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5KDH

CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A DIHYDROPYRIDOPYRIMIDINE SCAFFOLD INHIBITOR

Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue 6RX A 201
ChainResidue
ATRP81
AHOH342
APRO82
AVAL87
ALEU92
AASN116
AASN140
AILE146
AHOH307
AHOH320

site_idAC2
Number of Residues6
Detailsbinding site for residue EDO A 202
ChainResidue
ASER51
AASN52
ALYS57
ATRP81
ATYR118
AHOH313

site_idAC3
Number of Residues5
Detailsbinding site for residue SO4 A 203
ChainResidue
ALYS57
ALYS91
ALYS99
ALYS102
AHOH306

site_idAC4
Number of Residues2
Detailsbinding site for residue SO4 A 204
ChainResidue
AASP145
AMET149

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues106
DetailsDomain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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