5KDE

Inorganic pyrophosphatase from Mycobacterium tuberculosis in complex with inhibitor 1 and inorganic pyrophosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004427	molecular_function	inorganic diphosphate phosphatase activity
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006796	biological_process	phosphate-containing compound metabolic process
A	0016787	molecular_function	hydrolase activity
A	0044228	cellular_component	host cell surface
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue 6RT A 201

Chain	Residue
A	ARG101
A	TRP102
A	VAL105
A	ASP110
A	PRO112
A	PHE114

---

site_id	AC2
Number of Residues	9
Details	binding site for residue POP A 202

Chain	Residue
A	GLU85
A	HIS86
A	ASP89
A	TYR126
A	LYS127
A	HOH311
A	LYS16
A	ARG30
A	ASP84

---

Functional Information from PROSITE/UniProt

site_id	PS00387
Number of Residues	7
Details	PPASE Inorganic pyrophosphatase signature. DGDPLDA

Chain	Residue	Details
A	ASP52-ALA58

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"26296329","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26296329","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26296329","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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