5KCD

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with an N-methyl Substituted OBHS-N derivative

Replaces:  4ZUC

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue OB2 A 601

Chain	Residue
A	MET343
A	VAL418
A	GLU419
A	MET421
A	ILE424
A	GLY521
A	HIS524
A	LEU525
A	LEU540
A	HOH739
A	LEU346
A	THR347
A	ALA350
A	GLU353
A	LEU387
A	MET388
A	ARG394
A	PHE404

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site_id	AC2
Number of Residues	15
Details	binding site for residue OB2 B 601

Chain	Residue
B	THR347
B	ALA350
B	GLU353
B	LEU387
B	MET388
B	ARG394
B	PHE404
B	VAL418
B	GLU419
B	ILE424
B	GLY521
B	HIS524
B	LEU525
B	LEU540
B	HOH731

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
C	SER699
D	SER699

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site_id	SWS_FT_FI2
Number of Residues	88
Details	ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407

Chain	Residue	Details
A	ILE358-LEU378
A	ARG394-VAL418
B	ILE358-LEU378
B	ARG394-VAL418

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE

Chain	Residue	Details
A	TYR526
B	TYR526

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:7838153

Chain	Residue	Details
A	ALA340
B	ALA340

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Asymmetric dimethylarginine; by PRMT1 => ECO:0000269|PubMed:18657504, ECO:0000269|PubMed:24498420

Chain	Residue	Details
A	SER433
B	SER433

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