5KB6
High-resolution structure of the adenosine kinase from Mus musculus in complex with adenosine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004001 | molecular_function | adenosine kinase activity |
| A | 0004136 | molecular_function | deoxyadenosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006144 | biological_process | purine nucleobase metabolic process |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0006170 | biological_process | dAMP biosynthetic process |
| A | 0006175 | biological_process | dATP biosynthetic process |
| A | 0010613 | biological_process | positive regulation of cardiac muscle hypertrophy |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032261 | biological_process | purine nucleotide salvage |
| A | 0042102 | biological_process | positive regulation of T cell proliferation |
| A | 0044209 | biological_process | AMP salvage |
| A | 0044342 | biological_process | type B pancreatic cell proliferation |
| A | 0046085 | biological_process | adenosine metabolic process |
| A | 0046128 | biological_process | purine ribonucleoside metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0110052 | biological_process | toxic metabolite repair |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004001 | molecular_function | adenosine kinase activity |
| B | 0004136 | molecular_function | deoxyadenosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006144 | biological_process | purine nucleobase metabolic process |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0006170 | biological_process | dAMP biosynthetic process |
| B | 0006175 | biological_process | dATP biosynthetic process |
| B | 0010613 | biological_process | positive regulation of cardiac muscle hypertrophy |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0032261 | biological_process | purine nucleotide salvage |
| B | 0042102 | biological_process | positive regulation of T cell proliferation |
| B | 0044209 | biological_process | AMP salvage |
| B | 0044342 | biological_process | type B pancreatic cell proliferation |
| B | 0046085 | biological_process | adenosine metabolic process |
| B | 0046128 | biological_process | purine ribonucleoside metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0110052 | biological_process | toxic metabolite repair |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue ADN A 401 |
| Chain | Residue |
| A | THR281 |
| A | ALA343 |
| A | HOH544 |
| A | HOH564 |
| A | HOH565 |
| A | HOH588 |
| A | HOH603 |
| A | GLY283 |
| A | ARG284 |
| A | THR287 |
| A | ASP302 |
| A | GLN305 |
| A | ILE308 |
| A | ALA314 |
| A | HIS340 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | HIS77 |
| A | ALA78 |
| A | LYS87 |
| A | HOH503 |
| A | HOH556 |
| A | HOH596 |
| A | HOH607 |
| A | HOH623 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 403 |
| Chain | Residue |
| A | ASN30 |
| A | THR82 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue PG4 A 404 |
| Chain | Residue |
| A | SER344 |
| A | ARG348 |
| A | HOH578 |
| A | HOH728 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue PG4 A 405 |
| Chain | Residue |
| A | GLY251 |
| A | LYS263 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 406 |
| Chain | Residue |
| A | GLY313 |
| A | ALA314 |
| A | GLY315 |
| A | ASP316 |
| A | HOH627 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | binding site for residue ADN B 401 |
| Chain | Residue |
| B | THR281 |
| B | GLY283 |
| B | ARG284 |
| B | ASP302 |
| B | GLN305 |
| B | ILE308 |
| B | ALA314 |
| B | HIS340 |
| B | ALA343 |
| B | HOH540 |
| B | HOH549 |
| B | HOH553 |
| B | HOH575 |
| B | HOH622 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| B | HIS77 |
| B | ALA78 |
| B | LYS87 |
| B | HOH503 |
| B | HOH569 |
| B | HOH573 |
| B | HOH606 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 403 |
| Chain | Residue |
| B | ASN30 |
| B | THR82 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue PG4 B 404 |
| Chain | Residue |
| B | ASP302 |
| B | TYR341 |
| B | SER344 |
| B | ARG348 |
| B | HOH600 |
| B | HOH629 |
| B | HOH691 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 405 |
| Chain | Residue |
| B | GLY313 |
| B | ALA314 |
| B | GLY315 |
| B | ASP316 |
| B | HOH643 |
Functional Information from PROSITE/UniProt
| site_id | PS00584 |
| Number of Residues | 14 |
| Details | PFKB_KINASES_2 pfkB family of carbohydrate kinases signature 2. DTnGAGDafvGGFL |
| Chain | Residue | Details |
| A | ASP310-LEU323 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P55263","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P55263","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P55263","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
