5K89

Crystal Structure of Human Calcium-Bound S100A1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0008016	biological_process	regulation of heart contraction
A	0016529	cellular_component	sarcoplasmic reticulum
A	0021762	biological_process	substantia nigra development
A	0030018	cellular_component	Z disc
A	0031430	cellular_component	M band
A	0031672	cellular_component	A band
A	0031674	cellular_component	I band
A	0032991	cellular_component	protein-containing complex
A	0035556	biological_process	intracellular signal transduction
A	0042311	biological_process	vasodilation
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0044548	molecular_function	S100 protein binding
A	0046872	molecular_function	metal ion binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0051117	molecular_function	ATPase binding
A	1903672	biological_process	positive regulation of sprouting angiogenesis
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0008016	biological_process	regulation of heart contraction
C	0016529	cellular_component	sarcoplasmic reticulum
C	0021762	biological_process	substantia nigra development
C	0030018	cellular_component	Z disc
C	0031430	cellular_component	M band
C	0031672	cellular_component	A band
C	0031674	cellular_component	I band
C	0032991	cellular_component	protein-containing complex
C	0035556	biological_process	intracellular signal transduction
C	0042311	biological_process	vasodilation
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0044548	molecular_function	S100 protein binding
C	0046872	molecular_function	metal ion binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0051117	molecular_function	ATPase binding
C	1903672	biological_process	positive regulation of sprouting angiogenesis
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005829	cellular_component	cytosol
H	0008016	biological_process	regulation of heart contraction
H	0016529	cellular_component	sarcoplasmic reticulum
H	0021762	biological_process	substantia nigra development
H	0030018	cellular_component	Z disc
H	0031430	cellular_component	M band
H	0031672	cellular_component	A band
H	0031674	cellular_component	I band
H	0032991	cellular_component	protein-containing complex
H	0035556	biological_process	intracellular signal transduction
H	0042311	biological_process	vasodilation
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0044548	molecular_function	S100 protein binding
H	0046872	molecular_function	metal ion binding
H	0048306	molecular_function	calcium-dependent protein binding
H	0051117	molecular_function	ATPase binding
H	1903672	biological_process	positive regulation of sprouting angiogenesis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue TRS A 101

Chain	Residue
A	GLN39
A	SER43
H	GLU6
H	CYS86

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CA A 102

Chain	Residue
A	ASP63
A	ASN65
A	ASP67
A	GLU69
A	GLU74

---

site_id	AC3
Number of Residues	6
Details	binding site for residue CA A 103

Chain	Residue
A	SER20
A	GLU23
A	ASP25
A	LYS28
A	GLU33
A	HOH202

---

site_id	AC4
Number of Residues	6
Details	binding site for residue CA C 101

Chain	Residue
C	ASP63
C	ASN65
C	ASP67
C	GLU69
C	GLU74
C	HOH201

---

site_id	AC5
Number of Residues	5
Details	binding site for residue CA C 102

Chain	Residue
C	SER20
C	GLU23
C	ASP25
C	LYS28
C	GLU33

---

site_id	AC6
Number of Residues	5
Details	binding site for residue CA H 101

Chain	Residue
H	ASP63
H	ASN65
H	ASP67
H	GLU69
H	GLU74

---

site_id	AC7
Number of Residues	6
Details	binding site for residue CA H 102

Chain	Residue
H	SER20
H	GLU23
H	ASP25
H	LYS28
H	GLU33
H	HOH201

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DENGDGEVDfqEY

Chain	Residue	Details
A	ASP63-TYR75

---

site_id	PS00303
Number of Residues	22
Details	S100_CABP S-100/ICaBP type calcium binding protein signature. VMkeLDengDgevDFqEYvvLV

Chain	Residue	Details
A	VAL58-VAL79

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23351007","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28368280","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23351007","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28368280","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"22989881","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	35
Details	Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---