5K7J
Structure of designed zinc binding protein ZE2 bound to Zn2+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | L-tryptophan biosynthetic process |
| A | 0004425 | molecular_function | indole-3-glycerol-phosphate synthase activity |
| A | 0006568 | biological_process | L-tryptophan metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0000162 | biological_process | L-tryptophan biosynthetic process |
| B | 0004425 | molecular_function | indole-3-glycerol-phosphate synthase activity |
| B | 0006568 | biological_process | L-tryptophan metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue ZN A 301 |
| Chain | Residue |
| A | HIS179 |
| A | HIS183 |
| A | HIS210 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue ZN B 301 |
| Chain | Residue |
| B | HIS179 |
| B | HIS183 |
| B | HIS210 |
Functional Information from PROSITE/UniProt
| site_id | PS00614 |
| Number of Residues | 15 |
| Details | IGPS Indole-3-glycerol phosphate synthase signature. IIaEYKRKSPSgld....V |
| Chain | Residue | Details |
| A | ILE47-VAL61 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 252 |
| Chain | Residue | Details |
| A | GLU50 | electrostatic stabiliser, hydrogen bond acceptor, increase acidity, increase basicity, proton acceptor, proton donor |
| A | LYS52 | electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor |
| A | ALA109 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | GLY158 | activator, hydrogen bond acceptor, increase nucleophilicity |
| A | HIS179 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, increase acidity |
| A | ALA209 | electrostatic stabiliser |
| A | HIS210 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA2 |
| Number of Residues | 7 |
| Details | M-CSA 252 |
| Chain | Residue | Details |
| B | GLU50 | electrostatic stabiliser, hydrogen bond acceptor, increase acidity, increase basicity, proton acceptor, proton donor |
| B | LYS52 | electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor |
| B | ALA109 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | GLY158 | activator, hydrogen bond acceptor, increase nucleophilicity |
| B | HIS179 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, increase acidity |
| B | ALA209 | electrostatic stabiliser |
| B | HIS210 | electrostatic stabiliser, hydrogen bond donor |
