5K6R
Crystal structure of Arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003984 | molecular_function | acetolactate synthase activity |
| A | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 701 |
| Chain | Residue |
| A | ASP538 |
| A | ASN565 |
| A | HIS567 |
| A | TZD706 |
| A | HOH907 |
| site_id | AC2 |
| Number of Residues | 35 |
| Details | binding site for residue FAD A 702 |
| Chain | Residue |
| A | GLY309 |
| A | THR331 |
| A | LEU332 |
| A | MET333 |
| A | LEU349 |
| A | GLY350 |
| A | MET351 |
| A | HIS352 |
| A | GLY371 |
| A | VAL372 |
| A | ARG373 |
| A | ASP375 |
| A | ARG377 |
| A | VAL378 |
| A | ASP395 |
| A | ILE396 |
| A | ASP397 |
| A | GLU400 |
| A | GLY413 |
| A | ASP414 |
| A | VAL415 |
| A | GLN489 |
| A | MET490 |
| A | GLY508 |
| A | GLY509 |
| A | HOH801 |
| A | HOH817 |
| A | HOH823 |
| A | HOH847 |
| A | HOH852 |
| A | HOH856 |
| A | PHE206 |
| A | ARG246 |
| A | GLY307 |
| A | GLY308 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue 6R5 A 703 |
| Chain | Residue |
| A | GLY121 |
| A | VAL196 |
| A | PRO197 |
| A | PHE206 |
| A | GLN207 |
| A | LYS256 |
| A | ARG377 |
| A | TRP574 |
| A | SER653 |
| A | HOH820 |
| A | HOH1024 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue NHE A 704 |
| Chain | Residue |
| A | LYS220 |
| A | HIS221 |
| A | LEU273 |
| A | PRO274 |
| A | GLY275 |
| A | TYR276 |
| A | HOH807 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue K A 705 |
| Chain | Residue |
| A | MET543 |
| A | MET543 |
| A | GLN546 |
| A | GLN546 |
| site_id | AC6 |
| Number of Residues | 26 |
| Details | binding site for residue TZD A 706 |
| Chain | Residue |
| A | PRO119 |
| A | GLU144 |
| A | PRO170 |
| A | ASN174 |
| A | GLN207 |
| A | VAL485 |
| A | GLY486 |
| A | GLN487 |
| A | HIS488 |
| A | GLY511 |
| A | MET513 |
| A | ASP538 |
| A | GLY539 |
| A | SER540 |
| A | ASN565 |
| A | HIS567 |
| A | LEU568 |
| A | GLY569 |
| A | MET570 |
| A | VAL571 |
| A | MG701 |
| A | HOH820 |
| A | HOH841 |
| A | HOH859 |
| A | HOH907 |
| A | HOH1017 |
Functional Information from PROSITE/UniProt
| site_id | PS00187 |
| Number of Residues | 20 |
| Details | TPP_ENZYMES Thiamine pyrophosphate enzymes signature. IGasvanPdaivVdIdGDGS |
| Chain | Residue | Details |
| A | ILE521-SER540 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 32 |
| Details | Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32640464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z8N","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YBH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32640464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32640464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VZ8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19187232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32640464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19187232","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19187232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32640464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VZ8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Cysteine sulfinic acid (-SO2H)","evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19187232","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
