5K50

Three-dimensional structure of L-threonine 3-dehydrogenase from Trypanosoma brucei bound to NAD+ and L-allo-threonine refined to 2.23 angstroms

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
C	0003824	molecular_function	catalytic activity
E	0003824	molecular_function	catalytic activity
G	0003824	molecular_function	catalytic activity
I	0003824	molecular_function	catalytic activity
J	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	binding site for residue NAD A 1401

Chain	Residue
A	GLY1009
A	LEU1077
A	PRO1078
A	ALA1079
A	MET1081
A	ILE1095
A	PRO1117
A	SER1118
A	THR1119
A	TYR1144
A	LYS1148
A	GLY1012
A	LEU1171
A	PRO1172
A	ILE1174
A	GOL1402
A	HOH1509
A	HOH1517
A	HOH1531
A	HOH1539
A	GLN1013
A	ILE1014
A	ASP1035
A	VAL1036
A	LEU1054
A	ASP1055
A	CYS1056

---

site_id	AC2
Number of Residues	11
Details	binding site for residue GOL A 1402

Chain	Residue
A	MET1081
A	THR1119
A	ILE1120
A	TYR1144
A	LEU1171
A	PRO1172
A	GLY1173
A	THR1186
A	TRP1280
A	NAD1401
A	ACT1403

---

site_id	AC3
Number of Residues	6
Details	binding site for residue ACT A 1403

Chain	Residue
A	MET1081
A	SER1082
A	VAL1083
A	GLY1184
A	ALA1185
A	GOL1402

---

site_id	AC4
Number of Residues	27
Details	binding site for residue NAD C 1401

Chain	Residue
C	GLY1009
C	LEU1011
C	GLY1012
C	GLN1013
C	ILE1014
C	ASP1035
C	VAL1036
C	LEU1054
C	ASP1055
C	CYS1056
C	LEU1077
C	PRO1078
C	ALA1079
C	MET1081
C	ILE1095
C	SER1118
C	THR1119
C	TYR1144
C	LYS1148
C	LEU1171
C	PRO1172
C	GLY1173
C	ILE1174
C	ALO1402
C	HOH1517
C	HOH1527
C	HOH1536

---

site_id	AC5
Number of Residues	9
Details	binding site for residue ALO C 1402

Chain	Residue
C	MET1081
C	SER1082
C	THR1119
C	TYR1144
C	ALA1185
C	THR1186
C	TRP1280
C	NAD1401
C	ACT1403

---

site_id	AC6
Number of Residues	7
Details	binding site for residue ACT C 1403

Chain	Residue
C	MET1081
C	SER1082
C	VAL1083
C	ARG1084
C	GLY1184
C	ALA1185
C	ALO1402

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ACT C 1404

Chain	Residue
C	ARG1159
C	THR1236
C	ARG1237
C	THR1238

---

site_id	AC8
Number of Residues	27
Details	binding site for residue NAD E 1401

Chain	Residue
E	CYS1056
E	LEU1077
E	PRO1078
E	ALA1079
E	MET1081
E	ILE1095
E	PRO1117
E	SER1118
E	THR1119
E	TYR1144
E	LYS1148
E	LEU1171
E	PRO1172
E	ILE1174
E	GLY1182
E	GOL1403
E	HOH1506
E	HOH1509
E	HOH1520
E	GLY1009
E	GLY1012
E	GLN1013
E	ILE1014
E	ASP1035
E	VAL1036
E	LEU1054
E	ASP1055

---

site_id	AC9
Number of Residues	5
Details	binding site for residue GOL E 1402

Chain	Residue
E	ASP1017
E	SER1176
E	ALA1177
E	ALA1178
E	TYR1216

---

site_id	AD1
Number of Residues	6
Details	binding site for residue GOL E 1403

Chain	Residue
E	SER1082
E	THR1119
E	TYR1144
E	THR1186
E	TRP1280
E	NAD1401

---

site_id	AD2
Number of Residues	25
Details	binding site for residue NAD G 1401

Chain	Residue
G	GLY1009
G	GLY1012
G	GLN1013
G	ILE1014
G	ASP1035
G	VAL1036
G	LEU1054
G	ASP1055
G	CYS1056
G	LEU1077
G	PRO1078
G	ILE1095
G	PRO1117
G	SER1118
G	TYR1144
G	LYS1148
G	LEU1171
G	PRO1172
G	ILE1174
G	GLY1182
G	ALO1403
G	HOH1502
G	HOH1513
G	HOH1536
G	HOH1540

---

site_id	AD3
Number of Residues	4
Details	binding site for residue GOL G 1402

Chain	Residue
A	PRO1313
A	GLY1317
G	GLU1267
G	VAL1269

---

site_id	AD4
Number of Residues	9
Details	binding site for residue ALO G 1403

Chain	Residue
G	MET1081
G	SER1082
G	THR1119
G	TYR1144
G	GLY1184
G	ALA1185
G	THR1186
G	TRP1280
G	NAD1401

---

site_id	AD5
Number of Residues	25
Details	binding site for residue NAD I 1401

Chain	Residue
I	GLY1009
I	LEU1011
I	GLY1012
I	GLN1013
I	ILE1014
I	ASP1035
I	VAL1036
I	LEU1054
I	ASP1055
I	CYS1056
I	LEU1077
I	ALA1079
I	MET1081
I	ILE1095
I	PRO1117
I	SER1118
I	TYR1144
I	LYS1148
I	LEU1171
I	PRO1172
I	ILE1174
I	GLY1182
I	GOL1402
I	HOH1509
I	HOH1536

---

site_id	AD6
Number of Residues	8
Details	binding site for residue GOL I 1402

Chain	Residue
I	MET1081
I	SER1082
I	THR1119
I	TYR1144
I	GLY1184
I	ALA1185
I	THR1186
I	NAD1401

---

site_id	AD7
Number of Residues	6
Details	binding site for residue GOL I 1403

Chain	Residue
I	ASP1017
I	ALA1177
I	ALA1178
I	TYR1216
I	MET1217
I	ASP1307

---

site_id	AD8
Number of Residues	27
Details	binding site for residue NAD J 1401

Chain	Residue
J	GLY1009
J	GLY1012
J	GLN1013
J	ILE1014
J	ASP1035
J	VAL1036
J	LEU1054
J	ASP1055
J	CYS1056
J	LEU1077
J	PRO1078
J	ALA1079
J	MET1081
J	ILE1095
J	PRO1117
J	SER1118
J	THR1119
J	TYR1144
J	LYS1148
J	LEU1171
J	PRO1172
J	ILE1174
J	ACT1404
J	HOH1501
J	HOH1515
J	HOH1541
J	HOH1552

---

site_id	AD9
Number of Residues	6
Details	binding site for residue GOL J 1402

Chain	Residue
J	MET1081
J	SER1082
J	VAL1083
J	ARG1084
J	GLY1184
J	ALA1185

---

site_id	AE1
Number of Residues	5
Details	binding site for residue GOL J 1403

Chain	Residue
J	ASP1017
J	SER1176
J	ALA1177
J	TYR1216
J	MET1217

---

site_id	AE2
Number of Residues	4
Details	binding site for residue ACT J 1404

Chain	Residue
J	MET1081
J	THR1119
J	TYR1144
J	NAD1401

---