5K4V

Three-dimensional structure of L-threonine 3-dehydrogenase from Trypanosoma brucei bound to NAD+ refined to 2.2 angstroms

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
C	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	binding site for residue NAD A 1401

Chain	Residue
A	GLY1009
A	CYS1056
A	LEU1077
A	PRO1078
A	ALA1079
A	MET1081
A	ILE1095
A	PRO1117
A	SER1118
A	TYR1144
A	LYS1148
A	LEU1011
A	LEU1171
A	PRO1172
A	ILE1174
A	GLY1182
A	ACT1407
A	NA1411
A	HOH1504
A	HOH1523
A	HOH1529
A	HOH1540
A	GLY1012
A	HOH1541
A	HOH1545
A	GLN1013
A	ILE1014
A	ASP1035
A	VAL1036
A	LEU1054
A	ASP1055

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ACT A 1402

Chain	Residue
A	ASN1060
A	GLU1063
A	LYS1067
A	HOH1511

---

site_id	AC3
Number of Residues	3
Details	binding site for residue ACT A 1403

Chain	Residue
A	ALA1028
A	ASP1029
A	VAL1031

---

site_id	AC4
Number of Residues	3
Details	binding site for residue ACT A 1404

Chain	Residue
A	THR1072
A	ASN1111
A	HOH1547

---

site_id	AC5
Number of Residues	3
Details	binding site for residue ACT A 1405

Chain	Residue
A	SER1246
A	GLU1251
A	HOH1575

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ACT A 1406

Chain	Residue
A	GLU1105
A	TYR1158
A	TYR1162
C	ASP1090

---

site_id	AC7
Number of Residues	5
Details	binding site for residue ACT A 1407

Chain	Residue
A	MET1081
A	SER1082
A	THR1119
A	TYR1144
A	NAD1401

---

site_id	AC8
Number of Residues	6
Details	binding site for residue GOL A 1408

Chain	Residue
A	ASP1017
A	SER1176
A	ALA1177
A	ALA1178
A	TYR1216
A	GLN1311

---

site_id	AC9
Number of Residues	5
Details	binding site for residue GOL A 1409

Chain	Residue
A	ARG1159
A	LEU1232
A	LEU1235
A	THR1236
A	THR1238

---

site_id	AD1
Number of Residues	9
Details	binding site for residue GOL A 1410

Chain	Residue
A	TYR1162
A	GLY1163
A	HOH1546
A	HOH1586
C	LEU1207
C	PRO1208
C	TYR1209
C	GLU1210
C	ASN1278

---

site_id	AD2
Number of Residues	5
Details	binding site for residue NA A 1411

Chain	Residue
A	MET1081
A	ASP1187
A	NAD1401
A	HOH1523
A	HOH1540

---

site_id	AD3
Number of Residues	31
Details	binding site for residue NAD C 1401

Chain	Residue
C	PRO1172
C	ILE1174
C	GLY1182
C	ACT1402
C	HOH1514
C	HOH1519
C	HOH1525
C	HOH1530
C	HOH1534
C	HOH1556
C	GLY1009
C	LEU1011
C	GLY1012
C	GLN1013
C	ILE1014
C	ASP1035
C	VAL1036
C	LEU1054
C	ASP1055
C	CYS1056
C	LEU1077
C	PRO1078
C	ALA1079
C	MET1081
C	ILE1095
C	PRO1117
C	SER1118
C	THR1119
C	TYR1144
C	LYS1148
C	LEU1171

---

site_id	AD4
Number of Residues	7
Details	binding site for residue ACT C 1402

Chain	Residue
C	MET1081
C	SER1082
C	THR1119
C	TYR1144
C	TRP1280
C	NAD1401
C	HOH1507

---

site_id	AD5
Number of Residues	3
Details	binding site for residue ACT C 1403

Chain	Residue
A	THR1238
A	HOH1559
C	LYS1126

---

site_id	AD6
Number of Residues	6
Details	binding site for residue GOL C 1404

Chain	Residue
C	ASP1017
C	ALA1177
C	ALA1178
C	TYR1216
C	MET1217
C	PRO1218

---

site_id	AD7
Number of Residues	7
Details	binding site for residue GOL C 1405

Chain	Residue
A	ARG1159
A	GLN1160
A	LYS1161
C	GLU1270
C	GLN1274
C	LYS1275
C	ASN1278

---

site_id	AD8
Number of Residues	5
Details	binding site for residue GOL C 1406

Chain	Residue
A	TYR1268
C	ASP1058
C	ASN1060
C	GLY1061
C	HOH1546

---

site_id	AD9
Number of Residues	5
Details	binding site for residue GOL C 1407

Chain	Residue
C	ARG1159
C	LEU1232
C	LEU1235
C	ARG1237
C	HOH1554

---

site_id	AE1
Number of Residues	5
Details	binding site for residue GOL C 1408

Chain	Residue
C	LYS1133
C	ASP1134
C	ASP1135
C	ASN1288
C	HOH1506

---

site_id	AE2
Number of Residues	6
Details	binding site for residue NA C 1409

Chain	Residue
C	GLN1013
C	MET1081
C	PRO1181
C	ASP1187
C	HOH1525
C	HOH1530

---