5K47
CryoEM structure of the human Polycystin-2/PKD2 TRP channel
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0016020 | cellular_component | membrane |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0016020 | cellular_component | membrane |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0016020 | cellular_component | membrane |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 84 |
| Details | Transmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"27768895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27991905","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28092368","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"27768895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27991905","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28092368","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 152 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"27768895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27991905","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28092368","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"27768895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27991905","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28092368","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 172 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"27768895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27991905","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28092368","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"27768895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27991905","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28092368","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 84 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"27768895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27991905","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28092368","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 56 |
| Details | Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"27768895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27991905","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28092368","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"27768895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27991905","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28092368","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"28092368","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31806353","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6T9O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31806353","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38483987","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6T9O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28092368","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27768895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27991905","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28092368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32332171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38483987","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WB8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27768895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27991905","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28092368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32332171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38483987","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WB8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27768895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27991905","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28092368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32332171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38483987","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WB8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
