5K41

Structure of Mycobacterium thermoresistibile trehalose-6-phosphate synthase in a complex with ADP-glucose.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004805	molecular_function	trehalose-phosphatase activity
A	0005829	cellular_component	cytosol
A	0005946	cellular_component	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
A	0005992	biological_process	trehalose biosynthetic process
A	0016758	molecular_function	hexosyltransferase activity
A	0034605	biological_process	cellular response to heat
A	0070413	biological_process	trehalose metabolism in response to stress

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	binding site for residue ADQ A 501

Chain	Residue
A	TRP99
A	THR321
A	ARG361
A	VAL363
A	ARG365
A	LEU368
A	ASP385
A	GLY386
A	MET387
A	ASN388
A	LEU389
A	HIS168
A	VAL390
A	GLU393
A	HOH617
A	HOH641
A	HOH704
A	HOH713
A	HOH741
A	HOH823
A	HOH851
A	HIS199
A	ILE247
A	VAL284
A	ASP285
A	ARG286
A	LYS291
A	LEU319

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site_id	AC2
Number of Residues	8
Details	binding site for residue NHE A 502

Chain	Residue
A	GLU175
A	MET178
A	ARG183
A	ARG213
A	ARG384
A	GLU409
A	HOH685
A	HOH850

---

site_id	AC3
Number of Residues	8
Details	binding site for residue EDO A 503

Chain	Residue
A	LEU287
A	PRO322
A	SER323
A	GLU325
A	ARG334
A	HIS360
A	HOH624
A	HOH660

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 504

Chain	Residue
A	GLN298
A	ALA301
A	ARG339
A	GLN340
A	HIS343

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site_id	AC5
Number of Residues	6
Details	binding site for residue EDO A 505

Chain	Residue
A	ASN345
A	GLU350
A	PRO354
A	HIS357
A	TYR358
A	HOH601

---

site_id	AC6
Number of Residues	7
Details	binding site for residue EDO A 506

Chain	Residue
A	ARG213
A	LEU214
A	GLU444
A	ARG448
A	ARG451
A	HOH765
A	HOH845

---

site_id	AC7
Number of Residues	2
Details	binding site for residue EDO A 507

Chain	Residue
A	HIS430
A	ASP433

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