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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5K2B

2.5 angstrom A2a adenosine receptor structure with MR phasing using XFEL data

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001609	molecular_function	G protein-coupled adenosine receptor activity
A	0001973	biological_process	G protein-coupled adenosine receptor signaling pathway
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005506	molecular_function	iron ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue ZMA A 1201

Chain	Residue
A	LEU85
A	HOH1325
A	HOH1334
A	HOH1345
A	PHE168
A	GLU169
A	TRP246
A	LEU249
A	HIS250
A	ASN253
A	LEU267
A	MET270

site_id	AC2
Number of Residues	5
Details	binding site for residue NA A 1202

Chain	Residue
A	ASP52
A	SER91
A	HOH1327
A	HOH1340
A	HOH1355

site_id	AC3
Number of Residues	5
Details	binding site for residue CLR A 1203

Chain	Residue
A	PHE255
A	PHE258
A	CLR1205
A	OLC1207
A	HOH1311

site_id	AC4
Number of Residues	4
Details	binding site for residue CLR A 1204

Chain	Residue
A	CYS262
A	SER263
A	OLC1221
A	HOH1301

site_id	AC5
Number of Residues	4
Details	binding site for residue CLR A 1205

Chain	Residue
A	ALA72
A	ALA73
A	ILE80
A	CLR1203

site_id	AC6
Number of Residues	4
Details	binding site for residue OLB A 1206

Chain	Residue
A	THR65
A	PHE70
A	CYS71
A	OLC1221

site_id	AC7
Number of Residues	2
Details	binding site for residue OLC A 1207

Chain	Residue
A	PHE258
A	CLR1203

site_id	AC8
Number of Residues	4
Details	binding site for residue OLC A 1208

Chain	Residue
A	CYS28
A	VAL46
A	ARG205
A	OLC1209

site_id	AC9
Number of Residues	4
Details	binding site for residue OLC A 1209

Chain	Residue
A	TYR43
A	ILE125
A	TRP129
A	OLC1208

site_id	AD1
Number of Residues	4
Details	binding site for residue OLC A 1210

Chain	Residue
A	HIS75
A	MET140
A	LEU141
A	TYR179

site_id	AD2
Number of Residues	4
Details	binding site for residue OLC A 1212

Chain	Residue
A	PRO2
A	SER6
A	OLA1214
A	OLA1215

site_id	AD3
Number of Residues	3
Details	binding site for residue OLA A 1213

Chain	Residue
A	SER7
A	LEU19
A	LEU22

site_id	AD4
Number of Residues	1
Details	binding site for residue OLA A 1214

Chain	Residue
A	OLC1212

site_id	AD5
Number of Residues	3
Details	binding site for residue OLA A 1215

Chain	Residue
A	TYR290
A	OLC1212
A	HOH1302

site_id	AD6
Number of Residues	2
Details	binding site for residue OLA A 1216

Chain	Residue
A	ALA97
A	ILE124

site_id	AD7
Number of Residues	3
Details	binding site for residue OLA A 1217

Chain	Residue
A	ILE10
A	LEU14
A	OLC1220

site_id	AD8
Number of Residues	1
Details	binding site for residue OLA A 1218

Chain	Residue
A	THR11

site_id	AD9
Number of Residues	4
Details	binding site for residue OLC A 1220

Chain	Residue
A	THR65
A	THR68
A	OLA1217
A	OLC1221

site_id	AE1
Number of Residues	6
Details	binding site for residue OLC A 1221

Chain	Residue
A	PHE255
A	CYS262
A	CLR1204
A	OLB1206
A	OLC1220
A	HOH1301

site_id	AE2
Number of Residues	2
Details	binding site for residue OLC A 1222

Chain	Residue
A	HIS75
A	GLY76

site_id	AE3
Number of Residues	1
Details	binding site for residue OLA A 1223

Chain	Residue
A	LEU241

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIfSLLAIAIDRYIaI

Chain	Residue	Details
A	SER90-ILE106

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	VAL8-TRP32

site_id	SWS_FT_FI2
Number of Residues	28
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:18832607

Chain	Residue	Details
A	LEU33-ASN42
A	ASP101-ARG120

site_id	SWS_FT_FI3
Number of Residues	23
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	TYR43-ILE66

site_id	SWS_FT_FI4
Number of Residues	46
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:18832607

Chain	Residue	Details
A	SER67-CYS77
A	ASN144-PRO173
A	CYS259-PRO266

site_id	SWS_FT_FI5
Number of Residues	22
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	LEU78-ILE100

site_id	SWS_FT_FI6
Number of Residues	22
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	ALA121-TRP143

site_id	SWS_FT_FI7
Number of Residues	24
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	MET174-LEU198

site_id	SWS_FT_FI8
Number of Residues	23
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	LEU235-PHE258

site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	LEU267-TYR290

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:21593763, ECO:0007744\|PDB:2YDO

Chain	Residue	Details
A	GLU169
A	ASN253
A	SER277
A	HIS278

site_id	SWS_FT_FI11
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN154

site_id	SWS_FT_FI12
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
A	TRP1007
A	ILE1102

229380

PDB entries from 2024-12-25

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