5K1J

Human TTR altered by a rhenium tris-carbonyl Pyta-C8 derivative

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0006144	biological_process	purine nucleobase metabolic process
A	0007165	biological_process	signal transduction
A	0035578	cellular_component	azurophil granule lumen
A	0042802	molecular_function	identical protein binding
A	0070062	cellular_component	extracellular exosome
A	0070324	molecular_function	thyroid hormone binding
B	0005179	molecular_function	hormone activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0006144	biological_process	purine nucleobase metabolic process
B	0007165	biological_process	signal transduction
B	0035578	cellular_component	azurophil granule lumen
B	0042802	molecular_function	identical protein binding
B	0070062	cellular_component	extracellular exosome
B	0070324	molecular_function	thyroid hormone binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue DMS A 201

Chain	Residue
A	TRP41
A	LYS70
A	GLU72

---

site_id	AC2
Number of Residues	8
Details	binding site for residue EDO A 202

Chain	Residue
A	HOH305
A	HOH349
A	SER46
A	PHE64
A	VAL65
A	GLU66
A	ASN98
A	ASP99

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ACT A 203

Chain	Residue
A	ILE26
A	ASN27
A	TYR78
A	HOH310

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ACT A 204

Chain	Residue
A	VAL93
A	VAL94
B	TYR114
B	SER115

---

site_id	AC5
Number of Residues	5
Details	binding site for residue ACT A 205

Chain	Residue
A	PHE44
A	LYS48
A	LEU58
A	THR59
A	GLU63

---

site_id	AC6
Number of Residues	1
Details	binding site for residue RE A 206

Chain	Residue
A	THR96

---

site_id	AC7
Number of Residues	7
Details	binding site for residue DMS B 201

Chain	Residue
B	VAL71
B	ILE73
B	VAL93
B	ILE107
B	ALA109
B	TYR116
B	THR118

---

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO B 202

Chain	Residue
B	TRP41
B	LYS70
B	GLU72
B	HOH322

---

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO B 203

Chain	Residue
A	HIS90
B	TRP41
B	LYS70
B	GLU92

---

site_id	AD1
Number of Residues	2
Details	binding site for residue RE B 204

Chain	Residue
B	THR75
B	GLU89

---

site_id	AD2
Number of Residues	4
Details	binding site for residue IMD B 205

Chain	Residue
B	ASN27
B	ALA36
B	ALA37
B	THR49

---

Functional Information from PROSITE/UniProt

site_id	PS00768
Number of Residues	16
Details	TRANSTHYRETIN_1 Transthyretin signature 1. KVLDavrGsPAinVaV

Chain	Residue	Details
A	LYS15-VAL30

---

site_id	PS00769
Number of Residues	13
Details	TRANSTHYRETIN_2 Transthyretin signature 2. YTIAalLSPYSYS

Chain	Residue	Details
A	TYR105-SER117

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11418763, ECO:0007744|PDB:1ICT

Chain	Residue	Details
A	LYS15
A	GLU54
A	SER117
B	LYS15
B	GLU54
B	SER117

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Sulfocysteine => ECO:0000269|PubMed:17175208, ECO:0007744|PDB:2H4E

Chain	Residue	Details
A	CYS10
B	CYS10

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: 4-carboxyglutamate; in a patient with Moyamoya disease => ECO:0000269|PubMed:18221012

Chain	Residue	Details
A	GLU42
B	GLU42

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P02767

Chain	Residue	Details
A	SER52
B	SER52

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19167329

Chain	Residue	Details
A	ASN98
B	ASN98

---