5K1J
Human TTR altered by a rhenium tris-carbonyl Pyta-C8 derivative
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001523 | biological_process | retinoid metabolic process |
| A | 0003105 | biological_process | negative regulation of glomerular filtration |
| A | 0005179 | molecular_function | hormone activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006144 | biological_process | purine nucleobase metabolic process |
| A | 0007603 | biological_process | phototransduction, visible light |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0042562 | molecular_function | hormone binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0140313 | molecular_function | molecular sequestering activity |
| B | 0001523 | biological_process | retinoid metabolic process |
| B | 0003105 | biological_process | negative regulation of glomerular filtration |
| B | 0005179 | molecular_function | hormone activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006144 | biological_process | purine nucleobase metabolic process |
| B | 0007603 | biological_process | phototransduction, visible light |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0042562 | molecular_function | hormone binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0140313 | molecular_function | molecular sequestering activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 201 |
| Chain | Residue |
| A | TRP41 |
| A | LYS70 |
| A | GLU72 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 202 |
| Chain | Residue |
| A | HOH305 |
| A | HOH349 |
| A | SER46 |
| A | PHE64 |
| A | VAL65 |
| A | GLU66 |
| A | ASN98 |
| A | ASP99 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 203 |
| Chain | Residue |
| A | ILE26 |
| A | ASN27 |
| A | TYR78 |
| A | HOH310 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 204 |
| Chain | Residue |
| A | VAL93 |
| A | VAL94 |
| B | TYR114 |
| B | SER115 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 205 |
| Chain | Residue |
| A | PHE44 |
| A | LYS48 |
| A | LEU58 |
| A | THR59 |
| A | GLU63 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue RE A 206 |
| Chain | Residue |
| A | THR96 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue DMS B 201 |
| Chain | Residue |
| B | VAL71 |
| B | ILE73 |
| B | VAL93 |
| B | ILE107 |
| B | ALA109 |
| B | TYR116 |
| B | THR118 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 202 |
| Chain | Residue |
| B | TRP41 |
| B | LYS70 |
| B | GLU72 |
| B | HOH322 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 203 |
| Chain | Residue |
| A | HIS90 |
| B | TRP41 |
| B | LYS70 |
| B | GLU92 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue RE B 204 |
| Chain | Residue |
| B | THR75 |
| B | GLU89 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue IMD B 205 |
| Chain | Residue |
| B | ASN27 |
| B | ALA36 |
| B | ALA37 |
| B | THR49 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11418763, ECO:0007744|PDB:1ICT |
| Chain | Residue | Details |
| A | LYS15 | |
| A | GLU54 | |
| A | SER117 | |
| B | LYS15 | |
| B | GLU54 | |
| B | SER117 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Sulfocysteine => ECO:0000269|PubMed:17175208, ECO:0007744|PDB:2H4E |
| Chain | Residue | Details |
| A | CYS10 | |
| B | CYS10 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: 4-carboxyglutamate; in a patient with Moyamoya disease => ECO:0000269|PubMed:18221012 |
| Chain | Residue | Details |
| A | GLU42 | |
| B | GLU42 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P02767 |
| Chain | Residue | Details |
| A | SER52 | |
| B | SER52 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19167329 |
| Chain | Residue | Details |
| A | ASN98 | |
| B | ASN98 |
