5K0S
Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor Chem 1312
Replaces: 4LNEFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004825 | molecular_function | methionine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006431 | biological_process | methionyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004825 | molecular_function | methionine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006431 | biological_process | methionyl-tRNA aminoacylation |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| C | 0004825 | molecular_function | methionine-tRNA ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006412 | biological_process | translation |
| C | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| C | 0006431 | biological_process | methionyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue 0OU A 601 |
| Chain | Residue |
| A | ILE12 |
| A | ALA233 |
| A | TYR237 |
| A | HIS269 |
| A | TYR14 |
| A | ASP51 |
| A | HIS53 |
| A | GLY54 |
| A | MET227 |
| A | TYR228 |
| A | VAL229 |
| A | ASP232 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue 0OU B 601 |
| Chain | Residue |
| B | ALA11 |
| B | ILE12 |
| B | TYR14 |
| B | ASP51 |
| B | HIS53 |
| B | GLY54 |
| B | MET227 |
| B | TYR228 |
| B | VAL229 |
| B | ASP232 |
| B | ALA233 |
| B | TYR237 |
| B | HIS269 |
| B | HOH726 |
| B | HOH727 |
| B | HOH757 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue 0OU C 601 |
| Chain | Residue |
| C | ILE12 |
| C | TYR14 |
| C | ASP51 |
| C | HIS53 |
| C | GLY54 |
| C | MET227 |
| C | TYR228 |
| C | VAL229 |
| C | ASP232 |
| C | ALA233 |
| C | TYR237 |
| C | HIS269 |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 10 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. P..NGkPHIGHA |
| Chain | Residue | Details |
| A | PRO15-ALA24 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01228 |
| Chain | Residue | Details |
| A | LYS303 | |
| B | LYS303 | |
| C | LYS303 |
