Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0006584 | biological_process | catecholamine metabolic process |
| A | 0008171 | molecular_function | O-methyltransferase activity |
| A | 0016206 | molecular_function | catechol O-methyltransferase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0006584 | biological_process | catecholamine metabolic process |
| B | 0008171 | molecular_function | O-methyltransferase activity |
| B | 0016206 | molecular_function | catechol O-methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue 6P5 A 301 |
| Chain | Residue |
| A | GLY66 |
| A | TRP143 |
| A | ARG146 |
| B | ARG78 |
| A | TYR68 |
| A | MET89 |
| A | GLU90 |
| A | ILE91 |
| A | ALA118 |
| A | SER119 |
| A | GLN120 |
| A | HIS142 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | PRO82 |
| A | GLY83 |
| A | ARG85 |
| A | LYS111 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | ARG8 |
| A | TYR32 |
| A | LYS36 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 304 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue 6P5 B 301 |
| Chain | Residue |
| A | ARG78 |
| B | GLY66 |
| B | TYR68 |
| B | MET89 |
| B | GLU90 |
| B | ILE91 |
| B | SER119 |
| B | GLN120 |
| B | HIS142 |
| B | TRP143 |
| B | ARG146 |
| B | HOH417 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 302 |
| Chain | Residue |
| B | ARG8 |
| B | TYR32 |
| B | LYS36 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 303 |
| Chain | Residue |
| A | ARG11 |
| B | SER195 |
| B | SER196 |
| B | TYR197 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 304 |
| Chain | Residue |
| B | THR4 |
| B | LYS5 |
| B | HOH401 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 305 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01019","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12237326","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01019","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 915 |
| Chain | Residue | Details |
| A | ASP141 | metal ligand |
| A | LYS144 | proton shuttle (general acid/base) |
| A | ASP169 | metal ligand |
| A | ASN170 | metal ligand |
| A | GLU199 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 915 |
| Chain | Residue | Details |
| B | ASP141 | metal ligand |
| B | LYS144 | proton shuttle (general acid/base) |
| B | ASP169 | metal ligand |
| B | ASN170 | metal ligand |
| B | GLU199 | electrostatic stabiliser |
