Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0006584 | biological_process | catecholamine metabolic process |
| A | 0008171 | molecular_function | O-methyltransferase activity |
| A | 0016206 | molecular_function | catechol O-methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue 6P4 A 301 |
| Chain | Residue |
| A | ARG55 |
| A | HIS142 |
| A | TRP143 |
| A | GLY66 |
| A | TYR68 |
| A | MET89 |
| A | GLU90 |
| A | ILE91 |
| A | ALA118 |
| A | SER119 |
| A | GLN120 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue K A 302 |
| Chain | Residue |
| A | VAL183 |
| A | ARG184 |
| A | SER186 |
| A | PHE189 |
| A | HOH542 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255 |
| Chain | Residue | Details |
| A | ASP3-PRO19 | |
| Chain | Residue | Details |
| A | ARG85 | |
| A | LEU115 | |
| A | ASP133 | |
| A | ARG184 | |
| Chain | Residue | Details |
| A | GLY107 | |
| A | THR134 | |
| A | LYS162 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LEU160 | |
| A | SER187 | |
| A | TYR212 | |
| A | GLN213 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 915 |
| Chain | Residue | Details |
| A | ARG184 | metal ligand |
| A | SER187 | proton shuttle (general acid/base) |
| A | TYR212 | metal ligand |
| A | GLN213 | metal ligand |
