Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5JV2

Crystal structure of human FPPS in complex with an allosteric inhibitor MIT-01-055

Functional Information from GO Data
ChainGOidnamespacecontents
F0004659molecular_functionprenyltransferase activity
F0008299biological_processisoprenoid biosynthetic process
F0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue PO4 F 401
ChainResidue
FGLY56
FLYS57
FGLN96
FARG113
F6O3404
FHOH521
FHOH531

site_idAC2
Number of Residues1
Detailsbinding site for residue CL F 402
ChainResidue
FASP80

site_idAC3
Number of Residues3
Detailsbinding site for residue CL F 403
ChainResidue
FILE116
FARG346
FGLN115

site_idAC4
Number of Residues10
Detailsbinding site for residue 6O3 F 404
ChainResidue
FLYS57
FASN59
FARG60
FTHR63
FSER205
FPHE206
FPHE239
FLYS347
FPO4401
FHOH508

site_idAC5
Number of Residues8
Detailsbinding site for residue 6O3 F 405
ChainResidue
FTHR111
FGLY114
FGLN115
FILE116
FTYR322
FARG346
FTYR349
FHOH502

Functional Information from PROSITE/UniProt
site_idPS00444
Number of Residues13
DetailsPOLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. MGefFQIqDDYlD
ChainResidueDetails
FMET235-ASP247

site_idPS00723
Number of Residues15
DetailsPOLYPRENYL_SYNTHASE_1 Polyprenyl synthases signature 1. LVaDDim..DssltRRG
ChainResidueDetails
FLEU100-GLY114

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:16684881, ECO:0007744|PDB:1ZW5
ChainResidueDetails
FLYS57
FARG60
FGLN96
FASP103
FASP107
FARG113

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING:
ChainResidueDetails
FARG112
FLYS200
FTHR201
FGLN240
FLYS257

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
FLYS266

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Important for determining product chain length => ECO:0000250
ChainResidueDetails
FPHE98
FPHE99

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
FLYS57

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
FLYS287

227111

PDB entries from 2024-11-06

PDB statisticsPDBj update infoContact PDBjnumon