Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5JQL

Crystal Structure of Phosphatidic acid Transporter Ups1/Mdm35 Void of Bound Phospholipid from Saccharomyces Cerevisiae at 2.9 Angstroms Resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005758	cellular_component	mitochondrial intermembrane space
A	0006869	biological_process	lipid transport
A	0008289	molecular_function	lipid binding
A	0015914	biological_process	phospholipid transport
A	0032048	biological_process	cardiolipin metabolic process
A	0120010	biological_process	intermembrane phospholipid transfer
A	1990050	molecular_function	phosphatidic acid transfer activity
A	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
B	0003674	molecular_function	molecular_function
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005758	cellular_component	mitochondrial intermembrane space
B	0006869	biological_process	lipid transport
B	0007005	biological_process	mitochondrion organization
B	0015914	biological_process	phospholipid transport
B	0033108	biological_process	mitochondrial respiratory chain complex assembly
B	0097035	biological_process	regulation of membrane lipid distribution
B	0120010	biological_process	intermembrane phospholipid transfer
B	1990050	molecular_function	phosphatidic acid transfer activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005758	cellular_component	mitochondrial intermembrane space
C	0006869	biological_process	lipid transport
C	0008289	molecular_function	lipid binding
C	0015914	biological_process	phospholipid transport
C	0032048	biological_process	cardiolipin metabolic process
C	0120010	biological_process	intermembrane phospholipid transfer
C	1990050	molecular_function	phosphatidic acid transfer activity
C	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005758	cellular_component	mitochondrial intermembrane space
D	0006869	biological_process	lipid transport
D	0007005	biological_process	mitochondrion organization
D	0015914	biological_process	phospholipid transport
D	0033108	biological_process	mitochondrial respiratory chain complex assembly
D	0097035	biological_process	regulation of membrane lipid distribution
D	0120010	biological_process	intermembrane phospholipid transfer
D	1990050	molecular_function	phosphatidic acid transfer activity
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005758	cellular_component	mitochondrial intermembrane space
E	0006869	biological_process	lipid transport
E	0008289	molecular_function	lipid binding
E	0015914	biological_process	phospholipid transport
E	0032048	biological_process	cardiolipin metabolic process
E	0120010	biological_process	intermembrane phospholipid transfer
E	1990050	molecular_function	phosphatidic acid transfer activity
E	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
F	0003674	molecular_function	molecular_function
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005758	cellular_component	mitochondrial intermembrane space
F	0006869	biological_process	lipid transport
F	0007005	biological_process	mitochondrion organization
F	0015914	biological_process	phospholipid transport
F	0033108	biological_process	mitochondrial respiratory chain complex assembly
F	0097035	biological_process	regulation of membrane lipid distribution
F	0120010	biological_process	intermembrane phospholipid transfer
F	1990050	molecular_function	phosphatidic acid transfer activity
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005758	cellular_component	mitochondrial intermembrane space
G	0006869	biological_process	lipid transport
G	0008289	molecular_function	lipid binding
G	0015914	biological_process	phospholipid transport
G	0032048	biological_process	cardiolipin metabolic process
G	0120010	biological_process	intermembrane phospholipid transfer
G	1990050	molecular_function	phosphatidic acid transfer activity
G	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
H	0003674	molecular_function	molecular_function
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005758	cellular_component	mitochondrial intermembrane space
H	0006869	biological_process	lipid transport
H	0007005	biological_process	mitochondrion organization
H	0015914	biological_process	phospholipid transport
H	0033108	biological_process	mitochondrial respiratory chain complex assembly
H	0097035	biological_process	regulation of membrane lipid distribution
H	0120010	biological_process	intermembrane phospholipid transfer
H	1990050	molecular_function	phosphatidic acid transfer activity
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0005758	cellular_component	mitochondrial intermembrane space
I	0006869	biological_process	lipid transport
I	0008289	molecular_function	lipid binding
I	0015914	biological_process	phospholipid transport
I	0032048	biological_process	cardiolipin metabolic process
I	0120010	biological_process	intermembrane phospholipid transfer
I	1990050	molecular_function	phosphatidic acid transfer activity
I	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
J	0003674	molecular_function	molecular_function
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005758	cellular_component	mitochondrial intermembrane space
J	0006869	biological_process	lipid transport
J	0007005	biological_process	mitochondrion organization
J	0015914	biological_process	phospholipid transport
J	0033108	biological_process	mitochondrial respiratory chain complex assembly
J	0097035	biological_process	regulation of membrane lipid distribution
J	0120010	biological_process	intermembrane phospholipid transfer
J	1990050	molecular_function	phosphatidic acid transfer activity
K	0005515	molecular_function	protein binding
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0005758	cellular_component	mitochondrial intermembrane space
K	0006869	biological_process	lipid transport
K	0008289	molecular_function	lipid binding
K	0015914	biological_process	phospholipid transport
K	0032048	biological_process	cardiolipin metabolic process
K	0120010	biological_process	intermembrane phospholipid transfer
K	1990050	molecular_function	phosphatidic acid transfer activity
K	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
L	0003674	molecular_function	molecular_function
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005758	cellular_component	mitochondrial intermembrane space
L	0006869	biological_process	lipid transport
L	0007005	biological_process	mitochondrion organization
L	0015914	biological_process	phospholipid transport
L	0033108	biological_process	mitochondrial respiratory chain complex assembly
L	0097035	biological_process	regulation of membrane lipid distribution
L	0120010	biological_process	intermembrane phospholipid transfer
L	1990050	molecular_function	phosphatidic acid transfer activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	237
Details	Region: {"description":"Required for mitochondrial targeting","evidences":[{"source":"PubMed","id":"16754953","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26235513","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26071601","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26071601","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26235513","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	250
Details	Domain: {"description":"CHCH","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	60
Details	Motif: {"description":"Cx9C motif 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	60
Details	Motif: {"description":"Cx9C motif 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)