5JME

Crystal structure of acetylcholine binding protein (AChBP) from Aplysia Californica in complex with alpha-conotoxin PeIA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
F	0005576	cellular_component	extracellular region
F	0030550	molecular_function	acetylcholine receptor inhibitor activity
G	0005576	cellular_component	extracellular region
G	0030550	molecular_function	acetylcholine receptor inhibitor activity
H	0005576	cellular_component	extracellular region
H	0030550	molecular_function	acetylcholine receptor inhibitor activity
I	0005576	cellular_component	extracellular region
I	0030550	molecular_function	acetylcholine receptor inhibitor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI7
Number of Residues	60
Details	Peptide: {"description":"Alpha-conotoxin PeIA","featureId":"PRO_0000247851","evidences":[{"source":"PubMed","id":"15983035","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21252227","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Region: {"description":"Ser-Xaa-Pro motif, crucial for potent interaction with nAChR","evidences":[{"source":"UniProtKB","id":"P56636","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	16
Details	Site: {"description":"Important residue for inhibiting alpha-3-beta-2 nAChR","evidences":[{"source":"PubMed","id":"23846688","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Site: {"description":"Residue that is not optimum for the most potent inhibition of alpha-3-beta-2 and alpha-6/alpha-3-beta-2-beta-3 and alpha-6/alpha-3-beta-4","evidences":[{"source":"PubMed","id":"22914547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23846688","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Site: {"description":"Important residue for inhibiting alpha-3-beta-2 and alpha-6/alpha-3-beta-2-beta-3 nAChR","evidences":[{"source":"PubMed","id":"23846688","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"Cysteine amide","evidences":[{"source":"PubMed","id":"15983035","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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