5JKV

HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1) AT 2.75 ANGSTROM WITH BOUND POLYETHYLENE GLYCOL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0006703	biological_process	estrogen biosynthetic process
A	0006710	biological_process	androgen catabolic process
A	0006949	biological_process	syncytium formation
A	0008209	biological_process	androgen metabolic process
A	0008395	molecular_function	steroid hydroxylase activity
A	0008585	biological_process	female gonad development
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0016125	biological_process	sterol metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0032355	biological_process	response to estradiol
A	0046872	molecular_function	metal ion binding
A	0070330	molecular_function	aromatase activity
A	0101021	molecular_function	estrogen 2-hydroxylase activity
A	2000866	biological_process	positive regulation of estradiol secretion

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue HEM A 601

Chain	Residue
A	MET107
A	VAL373
A	ARG375
A	PHE430
A	GLY431
A	ARG435
A	GLY436
A	CYS437
A	MET446
A	MET447
A	ASD602
A	ARG115
A	ILE132
A	ILE133
A	TRP141
A	ARG145
A	ALA306
A	SER314
A	MET364

---

site_id	AC2
Number of Residues	11
Details	binding site for residue ASD A 602

Chain	Residue
A	ARG115
A	ILE133
A	TRP224
A	ALA306
A	ASP309
A	THR310
A	VAL370
A	LEU372
A	MET374
A	LEU477
A	HEM601

---

site_id	AC3
Number of Residues	10
Details	binding site for residue 1PE A 603

Chain	Residue
A	ARG145
A	MET149
A	GLU181
A	TYR424
A	GLN428
A	PHE432
A	GLY433
A	LYS440
A	TYR441
A	PO4607

---

site_id	AC4
Number of Residues	3
Details	binding site for residue PO4 A 604

Chain	Residue
A	SER72
A	ASN75
A	HIS475

---

site_id	AC5
Number of Residues	3
Details	binding site for residue PO4 A 605

Chain	Residue
A	HIS109
A	ASN110
A	HIS111

---

site_id	AC6
Number of Residues	4
Details	binding site for residue PO4 A 606

Chain	Residue
A	GLU342
A	ARG343
A	ASP344
A	ARG456

---

site_id	AC7
Number of Residues	4
Details	binding site for residue PO4 A 607

Chain	Residue
A	ARG145
A	GLY433
A	PRO434
A	1PE603

---

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGfGPRGCAG

Chain	Residue	Details
A	PHE430-GLY439

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"19129847","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3EQM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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