5JKV
HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1) AT 2.75 ANGSTROM WITH BOUND POLYETHYLENE GLYCOL
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0002677 | biological_process | negative regulation of chronic inflammatory response |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0006629 | biological_process | lipid metabolic process |
A | 0006694 | biological_process | steroid biosynthetic process |
A | 0006703 | biological_process | estrogen biosynthetic process |
A | 0006710 | biological_process | androgen catabolic process |
A | 0006949 | biological_process | syncytium formation |
A | 0008209 | biological_process | androgen metabolic process |
A | 0008395 | molecular_function | steroid hydroxylase activity |
A | 0008585 | biological_process | female gonad development |
A | 0009055 | molecular_function | electron transfer activity |
A | 0010760 | biological_process | negative regulation of macrophage chemotaxis |
A | 0016020 | cellular_component | membrane |
A | 0016125 | biological_process | sterol metabolic process |
A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
A | 0016712 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
A | 0019825 | molecular_function | oxygen binding |
A | 0020037 | molecular_function | heme binding |
A | 0030540 | biological_process | female genitalia development |
A | 0030879 | biological_process | mammary gland development |
A | 0032355 | biological_process | response to estradiol |
A | 0046872 | molecular_function | metal ion binding |
A | 0060065 | biological_process | uterus development |
A | 0060736 | biological_process | prostate gland growth |
A | 0061370 | biological_process | testosterone biosynthetic process |
A | 0070330 | molecular_function | aromatase activity |
A | 2000866 | biological_process | positive regulation of estradiol secretion |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 19 |
Details | binding site for residue HEM A 601 |
Chain | Residue |
A | MET107 |
A | VAL373 |
A | ARG375 |
A | PHE430 |
A | GLY431 |
A | ARG435 |
A | GLY436 |
A | CYS437 |
A | MET446 |
A | MET447 |
A | ASD602 |
A | ARG115 |
A | ILE132 |
A | ILE133 |
A | TRP141 |
A | ARG145 |
A | ALA306 |
A | SER314 |
A | MET364 |
site_id | AC2 |
Number of Residues | 11 |
Details | binding site for residue ASD A 602 |
Chain | Residue |
A | ARG115 |
A | ILE133 |
A | TRP224 |
A | ALA306 |
A | ASP309 |
A | THR310 |
A | VAL370 |
A | LEU372 |
A | MET374 |
A | LEU477 |
A | HEM601 |
site_id | AC3 |
Number of Residues | 10 |
Details | binding site for residue 1PE A 603 |
Chain | Residue |
A | ARG145 |
A | MET149 |
A | GLU181 |
A | TYR424 |
A | GLN428 |
A | PHE432 |
A | GLY433 |
A | LYS440 |
A | TYR441 |
A | PO4607 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue PO4 A 604 |
Chain | Residue |
A | SER72 |
A | ASN75 |
A | HIS475 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue PO4 A 605 |
Chain | Residue |
A | HIS109 |
A | ASN110 |
A | HIS111 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue PO4 A 606 |
Chain | Residue |
A | GLU342 |
A | ARG343 |
A | ASP344 |
A | ARG456 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue PO4 A 607 |
Chain | Residue |
A | ARG145 |
A | GLY433 |
A | PRO434 |
A | 1PE603 |
Functional Information from PROSITE/UniProt
site_id | PS00086 |
Number of Residues | 10 |
Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGfGPRGCAG |
Chain | Residue | Details |
A | PHE430-GLY439 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 40 |
Details | TRANSMEM: Helical => ECO:0000255 |
Chain | Residue | Details |
A | GLU19-TRP39 | |
A | MET303-ALA323 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP309 | |
A | MET374 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: axial binding residue => ECO:0000269|PubMed:19129847, ECO:0007744|PDB:3EQM |
Chain | Residue | Details |
A | CYS437 |